56287-74-2 Usage
Description
Different sources of media describe the Description of 56287-74-2 differently. You can refer to the following data:
1. Afloqualone is a centrally acting muscle relaxant useful in the management of
various spastic conditions, including cerebral palsy, cervical spondylosis, and
multiple sclerosis. It is closely related to the hypnotidsedative methaqualone.
2. Afloqualone (Item No. 21834) is an analytical reference standard categorized as a quinazolinone. This product is intended for research and forensic applications.
Originator
Tanabe (Japan)
Uses
Afloqualone acts as a muscle relaxant in humans and may be used in the treatment of muscle spasms affecting rheumatoid arthritis.
Manufacturing Process
14.4 g (0.053 mol) of N-(2-amino-5-nitrobenzoyl)-o-toluidine and 6.3 g (0.08
mol) of pyridine are dissolved in 300 ml of tetrahydrofuran. 12.2 g (0.126
mol) of fluoroacetyl chloride are added to the solution for 10 minutes under
ice-cooling. The solution is stirred at the same temperature for 30 minutes
and then at room temperature for 2.5 hours. The reaction solution is allowed
to stand at room temperature overnight. The crystalline precipitate is collected
by filtration, washed with water and then dried. 16.4 g of N-(2-
fluoroacetamido-5-nitrobenzoyl)-o-toluidine are obtained. Yield: 93.7%; MP
238-239°C.
16.5 g (0.05 mol) of N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine and
25.5 g (0.25 mol) of acetic acid anhydride are dissolved in 250 ml of glacial
acetic acid. The solution is refluxed for 2 hours under heating. Then, the
reaction solution is evaporated to remove solvent. The residue thus obtained
is poured into ice-water, and the aqueous mixture is adjusted to pH 9 with
potassium carbonate. The crystalline precipitate is collected by filtration. 15.5
g of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-quinazolinone are obtained.
Yield: 98.7%; MP 155-158°C (recrystallized from ethanol).
A mixture of 2.0 g (0.064 mol) of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-
quinazolinone, 0.2 g of 5% palladium-carbon and 100 ml of acetic acid is
shaken for 30 minutes in hydrogen gas. The initial pressure of hydrogen gas is
adjusted to 46 lb and the mixture is heated with an infrared lamp during the
reaction. After 30 minutes of this reaction, the pressure of hydrogen gas
decreases to 6 lb. After the mixture is cooled, the mixture is filtered to
remove the catalyst. The filtrate is evaporated to remove acetic acid, and the
residue is dissolved in chloroform. The chloroform solution is washed with 5%
aqueous sodium hydroxide and water, successively. Then, the solution is dried
and evaporated to remove solvent. The oily residue thus obtained is dissolved
in 2 ml of chloroform, and the chloroform solution is passed through a column
of 200 g of silica gel. The silica gel column is eluted with ethyl acetatebenzene
(1:1). Then, the eluate is evaporated to remove solvent. The crude
crystal obtained is washed with isopropyl ether and recrystallized from isopropanol. 0.95 g of 2-fluoromethyl-3-(o-tolyl)-6-amino-4(3H)-quinazolinone
is obtained. Yield: 52.5%; MP 195-196°C.
Brand name
AROFUTO
Therapeutic Function
Muscle relaxant
Check Digit Verification of cas no
The CAS Registry Mumber 56287-74-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,2,8 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 56287-74:
(7*5)+(6*6)+(5*2)+(4*8)+(3*7)+(2*7)+(1*4)=152
152 % 10 = 2
So 56287-74-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3
56287-74-2Relevant articles and documents
A method for preparing [...] (by machine translation)
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Paragraph 0063-0065, (2017/02/28)
The present invention discloses a afloqualone preparation method, which comprises: adopting an isatin anhydride as a starting raw material, carrying out nitration, reduction and acetylation to synthesize a key intermediate N-(2-amino-5-acetylaminobenzoyl)o-toluidine, and then carrying out aminolysis, cyclization, fluorine exchange and deprotection to obtain the target product afloqualone. The afloqualone preparation method has characteristics of cheap and easily-available raw materials, production cost reduction, elimination of use of highly-toxic and highly-harmful reagent fluoroacetyl chloride in the existing literature method, safety and environmental protection. In addition, tetrabutyl ammonium bromide is adopted as the phase transfer catalyst of the fluorine exchange reaction so as to substantially improve the conversion rate of the fluorine exchange reaction, and the total yield of the target product afloqualone prepared from the starting raw material isatin anhydride can be more than 60.0%.
