56289-67-9Relevant articles and documents
ALP-activated probe for diagnosis of liver injury by multispectral optoacoustic tomography
Wu, Yinglong,Zeng, Fang,Sun, Lihe,Chen, Junjie,Wu, Shuizhu
, p. 301 - 330 (2021)
In this chapter, we highlight the advantages of multispectral optoacoustic tomography (MSOT) technique and the activatable photoacoustic probes in the biomedical field, and give a brief introduction to enzyme-activated probes for disease diagnosis and therapeutic outcome evaluation. We also present a detailed description of the procedures for the synthesis of an activatable small molecule probe C1X-OR1 and confirmation of its specific response to alkaline phosphatase in solution and cells. With MSOT, the liposomal C1X-OR1 can be utilized for detection of hepatic ALP as well as for in vivo diagnosis of drug-induced liver injury in a three-dimensional manner.
Optimized Fluorescent Probe for Specific Imaging of Glutathione S-Transferases in Living Cells and Mice
Chen, Hui,Feng, Tian,Gai, Shouchang,Li, Xinxin,Shen, Xin,Song, Aiguo,Wei, Haiqing
, (2020)
GSTP1 has been considered to be a marker for malignancy in many tissues. However, the existing GST fluorescent probes are unfavorable for in vivo imaging because of the limited emission wavelength or insufficient fluorescence enhancement (six-fold). The limited fluorescence enhancement of GST fluorescent probes is mainly ascribed to the high background signals resulting from the spontaneous reaction between GSH and the probes. In this work, a highly specific GST probe with NIR emission has been successfully developed through optimization of the essential unit of the probe to repress the spontaneous reaction. The novel GST probe exhibits over 100-fold fluorescence enhancement upon incubation with GSTP1/GSH and high selectivity over other potential interference. In addition, the probe has been proved to be capable of tracking endogenous GST in A549 cells. Finally, the in vivo imaging results demonstrate that the probe can be used for effective imaging of endogenous GST activity in subcutaneous tumor mouse with high contrast.
Substitution nitrogen for chlorine of heptamethine cyanines for large Stokes shift fluorescent probes
Zheng, Lihui,Wang, Liqiu,Wang, Pengjun,Sun, Qi,Liu, Xuelong,Zhang, Xiaobo,Qiu, Shaobo
, p. 932 - 936 (2016)
On the basis of syntheses of three heptamethine indocyanines with methyl, ethyl, or p-carboxybenzyl groups on N atoms in the indole rings, nine novel aminoderivatives were designed and synthesized by butylamine, taurine, or benzylamine reacting with the indocyanines for substitution nitrogen for chlorine. The obtained products were purified by SiO2 column chromatography, and confirmed by ESI-MS and 1H NMR. Compared to the parents, the aminoderivatives showed blue shifts, larger Stokes shifts, and stronger fluorescence intensity, which were mainly related to the electron-donating ability of the amino substituents in the aminoderivatives. The stronger electron-donating ability of the amino substituents made the maximum absorption wavelengths show greater blue shifts.
A NIR fluorescent probe for the detection of fluoride ions and its application in in vivo bioimaging
Yang, Qiuyun,Jia, Chunman,Chen, Qing,Du, Wei,Wang, Yile,Zhang, Qi
, p. 2002 - 2009 (2017)
A novel near-infrared (NIR) fluorescent probe for the detection of fluoride ions has been developed, which is based on the F-triggered cleavage reaction of the Si-O bond. This probe exhibits excellent selectivity and sensitivity towards fluoride ions. The results of bioimaging experiments with HepG2 cells and mice show that the fluoride probe is available for visualizing exogenous fluoride ions in vitro and in vivo.
New cationic heptamethinecyanine-graphene hybrid materials
Prousis, Kyriakos C.,Canton-Vitoria, Ruben,Pagona, Georgia,Goulielmaki, Maria,Zoumpourlis, Vassilis,Tagmatarchis, Nikos,Calogeropoulou, Theodora
, (2019/12/27)
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