5632-33-7

Basic information

• Product Name: Quinazoline, 5,6,7,8-tetrahydro- (6CI,7CI,8CI,9CI)
• Synonyms: Quinazoline, 5,6,7,8-tetrahydro- (6CI,7CI,8CI,9CI);5,6,7,8-Tetrahydro-quinazoline
• CAS NO: 5632-33-7
• Molecular Formula: C8H10N2
• Molecular Weight: 134.1784
• Product Categories: PYRIMIDINE
• Mol File: 5632-33-7.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Quinazoline, 5,6,7,8-tetrahydro- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazoline, 5,6,7,8-tetrahydro- (6CI,7CI,8CI,9CI)(5632-33-7)
• EPA Substance Registry System: Quinazoline, 5,6,7,8-tetrahydro- (6CI,7CI,8CI,9CI)(5632-33-7)

Safety Data

• Hazardous Substances Data: 5632-33-7(Hazardous Substances Data)

Usage

General Description

Quinazoline, 5,6,7,8-tetrahydro- (6CI,7CI,8CI,9CI) is a chemical compound with the molecular formula C9H10N2. It is a heterocyclic organic compound that contains a quinazoline ring system. This chemical is a colorless liquid with a faint odor, and it is insoluble in water but soluble in organic solvents. Quinazoline, 5,6,7,8-tetrahydro- has applications in the pharmaceutical industry, where it is used as a building block for the synthesis of various drugs and pharmaceutical compounds. It also has potential applications as an intermediate in organic synthesis and chemical research. However, it is important to handle this chemical with care and in accordance with safety guidelines, as its precise properties and handling requirements may vary depending on the specific application.

Upstream product

• 108-94-1 cyclohexanone 
• 77287-34-4 formamide 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 17758-33-7 3-methyl-5-nitro-4(3H)-pyrimidinone 
• 290-87-9 1,3,5-Triazine 
• 19689-92-0 cyclohexanone O-acetyl oxime 
• 149-73-5 trimethyl orthoformate 
• 100-64-1 cyclohexanone-oxime 
• 3473-63-0 formamidine acetic acid 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 1680-73-5 2-chlorocyclohexene-1-carboxaldehyde 
• 1193-63-1 Cyclohexanone-2-carbaldehyde 

Downstream Products

• 89967-17-9 8-oxo-5,6,7,8-tetrahydroquinazoline 

Relevant articles and documents

Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes

Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.

Direct access to pyrimidines through organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine

An organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine through enamine catalysis has been developed. This method could furnish 4,5-disubstituted pyrimidines in good yields and high levels of regioselectivities.

One-step synthesis of 4,5-disubstituted pyrimidines using commercially available and inexpensive reagents

4,5-Disubstituted pyrimidines are synthesized from the corresponding ketone in one-step using inexpensive reagents (formamidine acetate, n-propanol, heat). Contrasted to other methods, this process appears quite amenable to large-scale use in industrial settings.