5636-10-2

Basic information

• Product Name: 4-tert-butyl-N,N-dimethylbenzenesulfonamide
• Synonyms: 4-tert-butyl-N,N-dimethylbenzenesulfonamide
• CAS NO: 5636-10-2
• Molecular Formula: C₁₂H₁₉NO₂S
• Molecular Weight: 241.34976
• Mol File: 5636-10-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-tert-butyl-N,N-dimethylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-butyl-N,N-dimethylbenzenesulfonamide(5636-10-2)
• EPA Substance Registry System: 4-tert-butyl-N,N-dimethylbenzenesulfonamide(5636-10-2)

Safety Data

• Hazardous Substances Data: 5636-10-2(Hazardous Substances Data)

Upstream product

• 58105-38-7 O-benzoyl N,N-dimethylhydroxylamine 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 15084-51-2 4-tert-butylbenzenesulfonyl chloride 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 68-12-2 N,N-dimethyl-formamide 
• 253185-03-4 tert-butylbenzene 
• 124-40-3 dimethyl amine 

Relevant articles and documents

Controlled synthesis of N, N-dimethylarylsulfonamide derivatives as nematicidal agents

Gramine can be intelligently and efficiently supplied with N, N-dimethylamino group and then reacted with the corresponding sulfonyl chlorides to synthesize N, N-dimethylarylsulfonamides. We herein designed and controlled synthesis of N, N-dimethylarylsulfonamide derivatives, and first reported the results of the nematicidal activity of 15 title compounds 3a-o against Meloidogyne incongnita in vitro, respectively. Among all of the title derivatives, compounds 3a, 3c, 3k, and 3o exhibited potent nematicidal activity with median lethal concentration (LC50) values ranging from 0.22 to 0.26 mg/L. Most noteworthy, N, N-dimethyl-4-methoxyphenylsulfonamide (3c) and N, N-dimethyl-8-quinolinesulfonamide (3o) showed the best promising and pronounced nematicidal activity, with LC50 values of 0.2381 and 0.2259 mg/L, respectively.

Potassium tert-butoxide-mediated metal-free synthesis of sulfonamides from sodium sulfinates and N,N-disubstituted formamides

By using formamides as amine sources, a novel and efficient KO-t-Bu mediated amination of sodium sulfinates has been developed. The reaction utilizes readily available starting materials under metal-free conditions, thus providing an alternative and attractive route to sulfonamides.

One-Pot Bimetallic Pd/Cu-Catalyzed Synthesis of Sulfonamides from Boronic Acids, DABSO and O-Benzoyl Hydroxylamines

A practical and straightforward bimetallic Pd/Cu catalytic system has been developed. This system affords various sulfonamides in one pot from easy-to-handle and readily available boronic acids, sulfur dioxide surrogate DABSO and O-benzoyl hydroxylamines in high yields. Without additional ligands, the newly developed catalytic system revealed a broad substrate scope for both partners and tolerated a wide array of functional groups even at low catalyst loadings. Furthermore, based on control experiments, a plausible mechanism has been proposed, in which sodium sulfinate has been isolated and identified as the crucial intermediate for this transformation.