56366-16-6Relevant articles and documents
Rhodium-Catalyzed Selective C-H Trideuteromethylation of Indole at C7 Position Using Acetic- d6 Anhydride
Han, Xiaowei,Yuan, Yu,Shi, Zhuangzhi
, p. 12764 - 12772 (2019)
Rhodium-catalyzed C7-selective decarbonylative trideuteromethylation of indoles with commercially available Ac2O-d6 via C-H and C-C bond activation has been developed. The key to the high reactivity and regioselectivity of this trans
Electro-Oxidative C-N Bond Formation through Azolation of Indole Derivatives: An Access to 3-Substituent-2-(Azol-1-yl)indoles
Zhou, Naifu,Zhao, Junhao,Sun, Chengbo,Lai, Yuqin,Ruan, Zhixiong,Feng, Pengju
, p. 16059 - 16067 (2021/10/01)
A practical protocol to synthesize 3-substituent-2-(azol-1-yl)indole derivatives has been developed via an electrochemical oxidative cross coupling process under mild conditions. This electro-oxidative C-N bond formation strategy tolerates a range of functional groups and is amenable to gram scale synthesis. Moreover, this method was applied to the late-stage functionalization of bioactive molecules.
Metal-free and regiospecific synthesis of 3-arylindoles
Xie, Wenlai,Xu, Chuangchuang,Xu, Jiaxi
, p. 2661 - 2671 (2020/04/17)
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ri
