56406-26-9

Basic information

• Product Name: 4-HYDROXY-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID
• Synonyms: 4-HYDROXY-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID;4-HYDROXY-2-PHENYL-PYRIMIDINE-5-CARBOXYLIC ACID ;4-Hydroxy-2-phenylpyrimidine-5-carboxylic acid ,95%;6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylic acid
• CAS NO: 56406-26-9
• Molecular Formula: C₁₁H₈N₂O₃
• Molecular Weight: 216.19
• Mol File: 56406-26-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 269-272°
• Boiling Point: 317.2 °C at 760 mmHg
• Flash Point: 145.7 °C
• Appearance: /
• Density: 1.4 g/cm³
• Vapor Pressure: 0.000164mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 4-HYDROXY-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID(56406-26-9)
• EPA Substance Registry System: 4-HYDROXY-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID(56406-26-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 56406-26-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C11H8N2O3/c14-10-8(11(15)16)6-12-9(13-10)7-4-2-1-3-5-7/h1-6H,(H,15,16)(H,12,13,14)

Upstream product

• 55613-22-4 4-hydroxy-2-phenyl-5-pyrimidinecarboxylic acid ethyl ester 
• 74222-83-6 benzamidine hydrochloride hydrate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 1670-14-0 benzamidine monohydrochloride 
• 24755-82-6 ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate 
• 97693-08-8 2-phenyl-5H-pyrido<1,2-a>pyrimido<5,4-e>pyrimidin-5-one 
• 49597-05-9 propene-1,1,3,3-tetracarboxylic acid tetraethyl ester 
• 613-92-3 N-hydroxybenzenecarboximidamide 

Downstream Products

• 343349-20-2 4-chloro-2-phenyl-pyrimidine-5-carboxylic acid 
• 310408-70-9 4-amino-2-phenylpyrimidine-5-carboxylic acid 
• 1562194-74-4 5-(1H-benzo[d]imidazo-2-yl)-2-phenylpyrimidin-4-amine 
• 1562194-78-8 3-phenylbenzo[4,5]imidazo[1,2-c]pyrimido[5,4-e]-pyrimidine-6(5H)-thione 
• 139438-57-6 N,N'-bis(6-phenyl-1H-pyrazolo<3,4-d>pyrimidin-3-yl)hydrazine 
• 139438-63-4 C₁₈H₁₄ClN₇S 
• 139438-61-2 7-(p-chlorophenylamino)-2-phenyl-9H-<1,2,4>triazolo<3',4':3,2>pyrazolo<3,4-d>pyrimidine 
• 139438-69-0 2-(6-phenyl-1H-pyrazolo<3,4-d>pyrimidin-3-yl)-p-chlorobenzenecarbohydrazide 
• 139438-60-1 7-(p-chlorophenyl)-2-phenyl-9H-<1,2,4>triazolo<3',4':3,2>pyrazolo<3,4-d>pyrimidine 
• 139438-50-9 3-(p-chlorobenzyl)amino-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 
• 139438-52-1 <(6-phenyl-1H-pyrazolo<3,4-d>pyrimidin-3-yl)thio>propanone 
• 139438-62-3 2-phenyl-9H-<1,2,4>triazolo<3',4':3,2>pyrazolo<3,4-d>pyrimidine-7(6H)-thione 
• 139438-64-5 2-phenyl-9H-tetrazolo<1',5':1,5>pyrazolo<3,4-d>pyrimidine 
• 139438-47-4 3-azido-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 

Relevant articles and documents

Tricyclic Heteroaromatic Systems Containing a Bridgehead Nitrogen Atom. Part 3. Triazolopyrazolopyrimidines, Tetrazolopyrazolopyrimidines and Pyrimidopyrazolotriazines

6-Phenyl-1H-pyrazolopyrimidin-3(2H)-one 16 has been prepared and converted into its 3-chloro 6, 3-thioxo 17 and 3-methylthio derivatives 9.Each of these could be converted into the 3-hydrazino derivative 3, cyclisation of which with carbon disulfide or triethyl orthoformate generated the fused 1,2,4-triazoles 23 and 20, respectively.Alternatively, the hydrazino derivative 3 gave a substituted hydrazide 26 or thiosemicarbazide 25, from which the 1,2,4-triazoles 21 and 22 respectively were obtained.The equilibrium between 3-azido-6-phenyl-1H-pyrazolopyrimidine 5 and 2-phenyl-9H-tetrazolopyrazolopyrimidine 27 was studied. 3-Diazo-4-methyl-6-phenyl-1H-pyrazolopyrimidine 29 was prepared by diazotisation of the corresponding amine 1 and converted into the 3-azido compound 4, which could not be cyclised to form a tetrazole.Finally, the diazo compound 29 readily formed the pyrimidopyrazolotriazine derivatives 32 and 33, when treated with pentane-2,4-dione and ethyl acetoacetate respectively.

Antiallergy agents. I. 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters

The synthesis of some 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters with potent oral and intravenous antiallergic activity against passive cutaneous anaphylaxis in the rat is described. Requirements for high activity include a free NH group in the pyrimidinone nucleus and a small to medium size ortho alkoxy or alkenyloxy group on the phenyl ring. It is suggested that in the case of the highly active compounds hydrogen bonding occurs between a nitrogen of the pyrimidine ring and the ethereal oxygen. The nature of this bonding and its possible contribution to an optimum configuration for the molecules is discussed.