56427-62-4Relevant articles and documents
Practical: In situ -generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters
Wang, Lin,Neumann, Helfried,Spannenberg, Anke,Beller, Matthias
supporting information, p. 7469 - 7472 (2017/07/12)
An effective method for alkoxycarbonylation of (hetero)aryl bromides is developed in the presence of in situ-generated phosphinite ligands tBu2POR (R = nBu, nPr, Et or Me). For this purpose commercially available tBu2PCl was used as the pre-ligand in the presence of different alcohols. For the first time cross coupling reactions with two alcohols-one generating the ligand, the other used as substrate-were developed. Through this method, ligand optimization can be performed in a more efficient manner and the desired products could be obtained with good yields and selectivity.
[18F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of β-amyloid fibrils
Lee, Ji Hoon,Byeon, Seong Rim,Kim, YoungSoo,Lim, Soo Jeong,Oh, Seung Jun,Moon, Dae Hyuk,Yoo, Kyung Ho,Chung, Bong Young,Kim, Dong Jin
scheme or table, p. 5701 - 5704 (2009/07/18)
In this study a novel series of isoindol-1-one and isoindol-1,3-dione derivatives for β-amyloid-specific binding agents is described. Twelve compounds were synthesized and evaluated via a competitive binding assay with [125I]TZDM against β-amyl