56430-08-1

Basic information

• Product Name: 2,3-DIMETHYL-1-(4-METHYLPHENYL)-3-PYRAZOLIN-5-ONE
• Synonyms: 4'-METHYLPHENAZONE;2,3-DIMETHYL-1-(4-METHYLPHENYL)-3-PYRAZOLIN-5-ONE;1,2-dihydro-1,5-dimethyl-2-(p-tolyl)-3H-pyrazol-3-one;2,3-DIMETHYL-1-(4-METHYLPHENYL)-3- PYRAZOLIN-5-ONE 99+%;1,5-DiMethyl-2-(p-tolyl)-1H-pyrazol-3(2H)-one
• CAS NO: 56430-08-1
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.25
• EINECS: 260-175-6
• Mol File: 56430-08-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 130-137 °C
• Boiling Point: 340.37°C (rough estimate)
• Flash Point: 131.8°C
• Appearance: /
• Density: 1.0838 (rough estimate)
• Vapor Pressure: 0.000485mmHg at 25°C
• Refractive Index: 1.6660 (estimate)
• Storage Temp.: Refrigerator (+4°C)
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2,3-DIMETHYL-1-(4-METHYLPHENYL)-3-PYRAZOLIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIMETHYL-1-(4-METHYLPHENYL)-3-PYRAZOLIN-5-ONE(56430-08-1)
• EPA Substance Registry System: 2,3-DIMETHYL-1-(4-METHYLPHENYL)-3-PYRAZOLIN-5-ONE(56430-08-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 24/25-26
• Hazardous Substances Data: 56430-08-1(Hazardous Substances Data)

Usage

Uses

A metabolite of the antipyrine analgesic drug Phenazone.

InChI:InChI=1/C12H14N2O/c1-9-4-6-11(7-5-9)14-12(15)8-10(2)13(14)3/h4-8H,1-3H3

Upstream product

• 35496-19-6 3-methyl-1-(4'-methylphenyl)-5-pyrazolone 
• 74-88-4 methyl iodide 
• 86-92-0 3-methyl-1-(4-methylphenyl)-2-pyrazolin-5-one 
• 141-97-9 ethyl acetoacetate 
• 539-44-6 N-4-methylphenylhydrazine 
• 74-83-9 methyl bromide 

Downstream Products

• 875232-48-7 1,5-dimethyl-2-p-tolyl-4-(2,2,2-trichloro-1-hydroxy-ethyl)-1,2-dihydro-pyrazol-3-one 
• 23461-59-8 2-Ethoxy-1-(p-acetamidophenylsulfonyl)-pyrrolidin 
• 153839-94-2 chloro(2,3-dimethyl-1-(4'-methylphenyl)-3-pyrazoline-5-one)(o-hydroxyacetophenonato)mercury(II) 

Relevant articles and documents

SCREENING METHODS AND THERAPEUTIC APPLICATIONS BASED ON BACTERIAL MOTILITY INHIBITION

The present invention relates to compounds for use in treating and/or preventing a bacterial infection or a condition associated with the bacterial infection, wherein the bacterial infection is caused by flagellated bacteria. The present invention further relates to a method of identifying compounds having bacterial anti-motility activity.

The selective condensation of pyrazolones to isatins in aqueous medium

The selective condensation of pyrazolones with isatins using water as the reaction medium is presented. This strategy provides an environmentally benign synthetic route to synthesize various potentially bioactive pyrazolone substituted oxindoles.

Room-temperature direct alkenylation of 5-pyrazolones

A mild and efficient method for the direct alkenylation of 5-pyrazoles by Pd-catalyzed C-H bond activation is described. The reaction smoothly proceeds at room temperature to provide products in up to 92 % yield. Heterocycles containing the 5-pyrazolone moiety are synthesized by an oxidative Heck-type reaction. The direct alkenylation of 5-pyrazolones at room temperature through Pd-catalyzed C-H bond activation is described. Copyright