564467-91-0

Basic information

• Product Name: 2-Methyl-6-nitro-2,3-dihydro-isoindol-1-one
• Synonyms: 2-Methyl-6-nitro-2,3-dihydro-isoindol-1-one;2-methyl-6-nitro-isoindolin-1-one
• CAS NO: 564467-91-0
• Molecular Formula: C9H8N2O3
• Molecular Weight: 192.17142
• Mol File: 564467-91-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 385.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.393±0.06 g/cm3(Predicted)
• PKA: -2.55±0.20(Predicted)
• CAS DataBase Reference: 2-Methyl-6-nitro-2,3-dihydro-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-6-nitro-2,3-dihydro-isoindol-1-one(564467-91-0)
• EPA Substance Registry System: 2-Methyl-6-nitro-2,3-dihydro-isoindol-1-one(564467-91-0)

Safety Data

• Hazardous Substances Data: 564467-91-0(Hazardous Substances Data)

Upstream product

• 77324-87-9 methyl 2-methyl-5-nitrobenzoate 
• 1975-52-6 5-nitro-o-toluic acid 
• 90725-68-1 methyl 2-(bromomethyl)-5-nitrobenzoate 
• 74-89-5 methylamine 
• 5342-91-6 2-methylisoindolin-1-one 

Downstream Products

• 69189-26-0 6-amino-2-methylisoindolin-1-one 
• 146748-07-4 3-benzylidene-2-methyl-6-nitro-isoindolin-1-one 

Relevant articles and documents

OGA INHIBITOR COMPOUNDS

The present invention relates to O-GIcNAc hydrolase (OGA) inhibitors of formula (I). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C90RF72 mutations.