565453-39-6 Usage
Description
Vildagliptin iMpurity K, also known as N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-prolinamide, is an impurity found in Vildagliptin (V305000), an oral anti-hyperglycemic agent used to treat type 2 diabetes. Vildagliptin works by inhibiting dipeptidyl peptidase 4 (DPP-4), an enzyme that breaks down insulin-regulating hormones, thus helping to improve blood sugar control.
Uses
Used in Pharmaceutical Industry:
Vildagliptin iMpurity K is used as a reference compound for quality control and analytical testing in the pharmaceutical industry. It helps ensure the purity and safety of Vildagliptin, the active ingredient in anti-hyperglycemic medications, by providing a benchmark for impurity levels.
Additionally, understanding the properties and effects of Vildagliptin iMpurity K can contribute to the development of improved drug formulations and the identification of potential side effects or interactions with other compounds in the treatment of diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 565453-39-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,6,5,4,5 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 565453-39:
(8*5)+(7*6)+(6*5)+(5*4)+(4*5)+(3*3)+(2*3)+(1*9)=176
176 % 10 = 6
So 565453-39-6 is a valid CAS Registry Number.
565453-39-6Relevant articles and documents
A preparation method of the peculiar smell degradation impurity
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Paragraph 0030; 0031; 0032; 0033; 0034; 0035; 0036; 0037, (2017/10/31)
The invention discloses a method for preparing vildagliptin degradation impurities. The method comprises the following steps: dissolving vildagliptin I in a solvent, adding an alkali solution, heating to 30-100 DEG C and reacting for 1-10 hours to obtain vildagliptin amide II. The method is short in synthetic route, simple and high in operability; the product meeting quality standards can be easily obtained through simple purification.
NEW PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF VILDAGLIPTIN
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Page/Page column 9; 10, (2013/06/27)
A new process for the synthesis of vildagliptin a via a novel intermediate formed by salification of prolinamide with haloacetic acid.
