565460-55-1

Basic information

• Product Name: methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate
• Synonyms: methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate
• CAS NO: 565460-55-1
• Molecular Weight: 220.228
• Mol File: 565460-55-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate(565460-55-1)
• EPA Substance Registry System: methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate(565460-55-1)

Safety Data

• Hazardous Substances Data: 565460-55-1(Hazardous Substances Data)

Upstream product

• 565460-54-0 dimethyl (2R)-2-(2-nitrophenylamino)butanedioate 
• 714568-86-2 dimethyl (2-nitrophenyl)-L-aspartate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 6384-18-5 dimethyl D-aspartate 

Downstream Products

• 1056950-86-7 (3R)-3-(2-aminoethyl)-4-[(3,4-dichloro-phenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one 
• 1053196-10-3 C₁₈H₁₈N₂O₅S 
• 1053196-09-0 C₁₇H₁₆N₂O₅S 
• 565460-58-4 N-[2-(4-cyanophenyl)ethyl]-2-{(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetamide 
• 565460-57-3 {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetic acid 
• 714567-80-3 2-[(2R)-3-Oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]-N-[2-(4-cyanophenyl)ethyl]acetamide 
• 942986-68-7 (2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl-acetic acid 
• 565460-56-2 methyl {(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate 

Relevant articles and documents

Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists

Replacement of the core β-amino acid in our previously reported piperidine acetic acid and β-phenylalanine-based Bradykinin B1 antagonists by dihydroquinoxalinone acetic acid increases the in vitro potency and metabolic stability. The most potent compounds from this series have IC50s a human B1 receptor functional assay. A molecular modeling study of the binding modes of key compounds, based on a B1 homology model, explains the structure-activity relationship (SAR) for these analogs.

Development of an efficient and selective radioligand for bradykinin B 1 receptor occupancy studies

We have developed an efficient and selective radioligand, the [ 35S]-radiolabeled dihydroquinoxalinone derivative, 4, for an ex vivo receptor occupancy assay in transgenic rats over-expressing the human bradykinin B1 receptor.

Discovery of a potent, non-peptide bradykinin B1 receptor antagonist

Bradykinin (BK) plays an important role in the pathophysiological processes accompanying pain and inflammation. Selective bradykinin B1 receptor antagonists have been shown to be anti-nociceptive in animal models and could be novel therapeutic