5658-50-4

Basic information

• Product Name: 1-(3,4,5-trimethoxyphenyl)propan-1-one
• Synonyms: 1-(3,4,5-trimethoxyphenyl)propan-1-one
• CAS NO: 5658-50-4
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.253
• Mol File: 5658-50-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 53–56°C
• Boiling Point: 321.7°C at 760 mmHg
• Flash Point: 139.7°C
• Density: 1.07g/cm³
• Vapor Pressure: 0.000294mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: 1-(3,4,5-trimethoxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4,5-trimethoxyphenyl)propan-1-one(5658-50-4)
• EPA Substance Registry System: 1-(3,4,5-trimethoxyphenyl)propan-1-one(5658-50-4)

Safety Data

• Hazardous Substances Data: 5658-50-4(Hazardous Substances Data)

Usage

Preparation

Obtained by reaction of 5% ethanolic potassium hydroxide with 2-(3,4,5-trimethoxybenzoyl)-2-methylacetic acid ethyl ester (m.p. 40°) at 60° for 1 h(76%).

Upstream product

• 3044-56-2 ethyl trimethoxybenzoyl acetate 
• 76774-00-0 1-(3,4,5-trimethoxyphenyl)prop-2-en-1-ol 
• 557-20-0 diethylzinc 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 758-96-3 N,N-dimethyl-propanamide 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 118-41-2 Eudesmic acid 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 41564-88-9 1-(3',4',5'-trimethoxyphenyl)propane 
• 10028-15-6 ozone 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 1575-15-1 ethyl 2-methyl-3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate 

Downstream Products

• 68143-87-3 2,2-Dibromo-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 527750-41-0 (E)-3-(3-fluoro-4-methoxyphenyl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 527750-42-1 (E)-3-(3,5-difluoro-4-methoxyphenyl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1202071-86-0 (E)-2-methyl-1-(3,4,5-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 527750-74-9 (E)-3-(4-methoxy-3-nitrophenyl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 41564-88-9 1-(3',4',5'-trimethoxyphenyl)propane 
• 25173-72-2 3-(3,4,5-trimethoxyphenyl)propanoic acid 

Relevant articles and documents

Alpha,beta-unsaturated ketone derivatives, preparation method of derivatives and application of derivatives as medicines

The invention relates to the technical field of medicine, and proposes alpha,beta-unsaturated ketone derivatives and a preparation method thereof. The derivatives have a structural general formula represented by a formula I shown in the specification, whe

Magnesium salt promoted tandem nucleophilic addition-Oppenauer oxidation of aldehydes with organozinc reagents

A magnesium salt promoted synthesis of ketones via tandem nucleophilic addition-Oppenauer oxidation of aldehydes using organozinc chemistry was demonstrated. Magnesium salts concomitantly generated via magnesium metal mediated organohalide zincation exhibit high efficacy for nucleophilic addition of organozinc reagents to aromatic aldehydes and thereafter Oppenauer oxidation whereby ketones are formed in high to excellent yields.

Efficient synthesis of alkyl aryl ketones & ketals via palladium-catalyzed regioselective arylation of vinyl ethers

The combination of Pd(OAc)2 with 1,3-bis(diphenylphosphino) propane (dppp) in ethylene glycol constitutes a high-performance catalytic system for highly regioselective arylation of a range of electron-rich vinyl ethers by aryl bromides to provide, upon hydrolysis, alkyl aryl ketones and cyclic ketals in good yields with up to 3.75 × 105 TON and 15625 h-1 TOF.