566-27-8 Usage
Description
7BETA-HYDROXYCHOLESTEROL, also known as 7β-Hydroxycholesterol, is a metabolite of cholesterol that is characterized by its white solid appearance. It possesses unique membrane organizing properties, which have been found to have potential implications in the development and progression of Alzheimer's disease.
Uses
Used in Pharmaceutical Industry:
7BETA-HYDROXYCHOLESTEROL is used as a research compound for its potential role in Alzheimer's disease. Its membrane organizing properties make it a valuable tool in studying the effects of cholesterol metabolism on the development and progression of this neurodegenerative disorder.
Used in Chemical Research:
As a metabolite of cholesterol, 7BETA-HYDROXYCHOLESTEROL is used as a chemical intermediate in the synthesis of various compounds and pharmaceuticals. Its unique properties and reactivity make it a useful building block in the development of new drugs and therapies.
Used in Diagnostic Applications:
7BETA-HYDROXYCHOLESTEROL can be used as a biomarker in the diagnosis and monitoring of cholesterol-related conditions and diseases. Its presence in the body can provide valuable information about an individual's cholesterol metabolism and potential risk for developing Alzheimer's disease or other related conditions.
Used in Nutritional Supplements:
Due to its connection with cholesterol metabolism, 7BETA-HYDROXYCHOLESTEROL may be used as an ingredient in nutritional supplements designed to support healthy cholesterol levels and overall cardiovascular health. However, it is essential to note that the use of this compound in supplements should be carefully regulated and monitored to ensure safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 566-27-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 566-27:
(5*5)+(4*6)+(3*6)+(2*2)+(1*7)=78
78 % 10 = 8
So 566-27-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24+,25+,26+,27-/m1/s1
566-27-8Relevant articles and documents
Cholesterol degradation in archaeological pottery mediated by fired clay and fatty acid pro-oxidants
Hammann, Simon,Cramp, Lucy J.E.,Whittle, Mathilda,Evershed, Richard P.
, p. 4401 - 4404 (2018)
Cholesterol is generally absent in animal fat residues preserved in archaeological ceramic vessels. It is known from edible oil refining that during bleaching with activated clay sterols are degraded, largely via oxidation. Laboratory heating experiments
Metal-Free Allylic Oxidation of Steroids Using TBAI/TBHP Organocatalytic Protocol
Lam, Ying-Pong,Yeung, Ying-Yeung
supporting information, p. 2369 - 2372 (2018/04/19)
A mild, efficient and organocatalytic allylic oxidation of steroids using a TBAI/TBHP protocol has been developed. A range of bioactive Δ5-en-7-ones can be easily prepared from the corresponding Δ5-steroids. The methodology features several advantages, including readily available starting materials, environmentally benign oxidant, high functional group compatibility, and metal-free catalysis.
Cholesterol transformations during heat treatment
Derewiaka,Molińska
, p. 233 - 240 (2015/01/09)
The aim of the study was to characterise products of cholesterol standard changes during thermal processing. Cholesterol was heated at 120 °C, 150 °C, 180 °C and 220 °C from 30 to 180 min. The highest losses of cholesterol content were found during thermal processing at 220 °C, whereas the highest content of cholesterol oxidation products was observed at temperature of 150 °C. The production of volatile compounds was stimulated by the increase of temperature. Treatment of cholesterol at higher temperatures i.e. 180 °C and 220 °C led to the formation of polymers and other products e.g. cholestadienes and fragmented cholesterol molecules. Further studies are required to identify the structure of cholesterol oligomers and to establish volatile compounds, which are markers of cholesterol transformations, mainly oxidation.