56625-03-7

Basic information

• Product Name: N-(pyridin-2-ylmethyl)formamide
• CAS NO: 56625-03-7
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.1512
• Mol File: 56625-03-7.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 346.6°C at 760 mmHg
• Flash Point: 163.4°C
• Density: 1.119g/cm³
• Vapor Pressure: 5.7E-05mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: N-(pyridin-2-ylmethyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(pyridin-2-ylmethyl)formamide(56625-03-7)
• EPA Substance Registry System: N-(pyridin-2-ylmethyl)formamide(56625-03-7)

Safety Data

• Hazardous Substances Data: 56625-03-7(Hazardous Substances Data)

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 50-00-0 formaldehyd 
• 67-56-1 methanol 
• 77287-34-4 formamide 
• 201230-82-2 carbon monoxide 
• 124-38-9 carbon dioxide 
• 2258-42-6 formyl acetic anhydride 
• 109-94-4 formic acid ethyl ester 
• 64-18-6 formic acid 

Downstream Products

• 274-47-5 imidazo[1,5-a]pyridine 
• 21035-59-6 N-methyl-2-pyridinemethanamine 
• 173344-98-4 1-acetylimidazo<1,5-a>pyridine 
• 23950-04-1 a-Nicotine 
• 42182-32-1 2-(N-Methyl-N-formyl-aminomethyl)-pyridin 

Relevant articles and documents

Highly Efficient and Selective N-Formylation of Amines with CO2 and H2 Catalyzed by Porous Organometallic Polymers

The valorization of carbon dioxide (CO2) to fine chemicals is one of the most promising approaches for CO2 capture and utilization. Herein we demonstrated a series of porous organometallic polymers could be employed as highly efficient and recyclable catalysts for this purpose. Synergetic effects of specific surface area, iridium content, and CO2 adsorption capability are crucial to achieve excellent selectivity and yields towards N-formylation of diverse amines with CO2 and H2 under mild reaction conditions even at 20 ppm catalyst loading. Density functional theory calculations revealed not only a redox-neutral catalytic pathway but also a new plausible mechanism with the incorporation of the key intermediate formic acid via a proton-relay process. Remarkably, a record turnover number (TON=1.58×106) was achieved in the synthesis of N,N-dimethylformamide (DMF), and the solid catalysts can be reused up to 12 runs, highlighting their practical potential in industry.

METHOD OF CARBON MONOXIDE FIXATION AND METHOD OF AMINE FORMYLATION

The present invention relates to a method for fixing carbon monoxide in a metal-free condition and a method for formating amine using the same.

Method for preparing formamide compound by catalyzing carbon dioxide hydrogenation with porous material

The invention belongs to the technical field of organic synthesis and heterogeneous catalysis, and particularly relates to a method for preparing a formamide compound by catalyzing carbon dioxide hydrogenation through a porous material. The method comprises the following steps: by taking a porous organic metal polymer as a catalyst, reacting an amine compound with carbon dioxide and hydrogen in anair atmosphere to prepare the formamide compound. The method has the advantages of high reaction efficiency, good selectivity, mild conditions, economy, environmental protection, simple operation andthe like; wherein a solid metal polymer material with large specific surface area, strong carbon dioxide adsorption, hierarchical pore channel distribution and highly dispersed metal centers is designed and synthesized as a reaction catalyst by changing a cross-linked copolymer proportion; the catalyst is especially used for catalytic synthesis of fine chemical N, N-dimethylformamide (DMF), doesnot need any additional solvent, alkali or other additives, and is convenient for separation and purification of DMF. The catalyst can be recycled; no special equipment is needed in the reaction, thereaction operation is simple, and further industrial application is facilitated.