56800-31-8Relevant articles and documents
2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms
Datta, Dhrubajyoti,Debnath, Joy,Franzblau, Scott G.,Ghosh, Kalyan Sundar,Hari, Natarajan,Ma, Rui,Rana, Shiwani,Velappan, Anand Babu
, (2020/09/04)
The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.
Liquid crystal dimers having vary oxyethylene flexible spacers
Park, Joo Hoon,Singu, Bal Sydulu,Choi, Ok Byung,Lee, Hwan Myung,Lee, Jin Young,Kim, Sung Jo,Cha, Eun Hee,Park, Seon Nam,Kwak, Myeong Heon,So, Bong Keun,Kim, Ran Hee,Lee, Soo Min,Yoon, Kuk Ro
, p. 1 - 6 (2017/09/07)
In this article, we are prepared that the liquid crystal dimers have aromatic-ester type mesogenic units or aromatic-Schiff base type mesogonic units and confirmed by 1H-NMR spectrometry. The mesomorphic and optical properties of the resultant dimers were studied by differential scanning calorimetry and polarizing optical microscopy.
Mesomorphic, micro-Raman and DFT studies of new calamitic liquid crystals; Methyl 4-[4-(4-alkoxy benzoyloxy)benzylideneamino]benzoates
Nandi, Rajib,Singh, Hemant Kumar,Singh, Sachin Kumar,Singh, Bachcha,Singh, Ranjan K.
supporting information, p. 248 - 256 (2014/04/17)
The mesomorphic properties of newly synthesized homologous series of calamitic liquid crystals; methyl 4-[4-(4-alkoxy benzoyloxy)benzylideneamino] benzoates, H2n+1CnOC 6H4COOC6H4C(H)N C6H 4COOCH3; n = 6, 8, 10, 12, 14, 16 (MABBAB-n) containing ester and Schiff base groups as linker have been studied by temperature dependent micro-Raman study, differential scanning calorimetry (DSC) and polarizing optical microscopy (POM). All members of this series exhibit enantiotropic smectic A (SmA) mesophase with oily streak and focal conic textures. Analyses of Raman marker bands of phenyl rings, Schiff base and ester groups of MABBAB-10 confirm the phase transitions. The Raman study also gives an evidence of breaking of weak intermolecular hydrogen bonds associated with ester groups and formation of new hydrogen bonds through CN bond at Cr → SmA phase transition. The monomer and dimer were optimized and vibrational assignment of MABBAB-10 was also done with density functional theoretical (DFT) technique to understand the experimental results.
