56842-77-4 Usage
Description
Cefazolin IMpurity C, also known as 7-[1-(1H)-Tetrazolylacetamido]desacetoxycephalosporanic Acid, is an impurity found in Cefazolin (C242500), a semi-synthetic antibiotic derived from 7-amino-cephalosporanic acid. It is characterized by its tetrazolyl and acetamido functional groups, which contribute to its chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
Cefazolin IMpurity C is used as an impurity in the production of Cefazolin, a widely used semi-synthetic antibiotic with potent antibacterial properties. It is essential to monitor and control the levels of this impurity to ensure the safety, efficacy, and quality of the final antibiotic product.
Used in Research and Development:
Cefazolin IMpurity C serves as a valuable compound for researchers in the field of pharmaceuticals and medicinal chemistry. It can be used to study the structure-activity relationship of Cefazolin and its analogs, potentially leading to the development of new and improved antibiotics with enhanced properties.
Used in Quality Control and Regulatory Compliance:
Cefazolin IMpurity C is utilized in the quality control processes of pharmaceutical manufacturers to ensure that the final product meets the required standards and regulations. By analyzing and quantifying the presence of this impurity, manufacturers can maintain the safety and efficacy of Cefazolin and comply with regulatory guidelines.
Used in Drug Interaction Studies:
Cefazolin IMpurity C can be employed in drug interaction studies to investigate potential side effects, toxicity, and synergistic effects when Cefazolin is administered in combination with other medications. This information is crucial for the development of safe and effective drug regimens for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 56842-77-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,8,4 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 56842-77:
(7*5)+(6*6)+(5*8)+(4*4)+(3*2)+(2*7)+(1*7)=154
154 % 10 = 4
So 56842-77-4 is a valid CAS Registry Number.
56842-77-4Relevant articles and documents
Influence of substrate structure on PGA-catalyzed acylations. Evaluation of different approaches for the enzymatic synthesis of cefonicid
Terreni, Marco,Tchamkam, Joseph Gapesie,Sarnataro, Umberto,Rocchietti, Silvia,Fernandez-Lafuente, Roberto,Guisan, Jose M.
, p. 121 - 128 (2007/10/03)
The influence of the substrate structure on the catalytic properties of penicillin G acylase (PGA) from Escherichia coli in kinetically controlled acylations has been studied. In particular, the affinity of different β-lactam nuclei towards the active site has been evaluated considering the ratio between the rate of synthesis (vs) and the rate of hydrolysis of the acylating ester (vhl). 7-Aminocephalosporanic acid (7-ACA) and 7-amino-3-(1-sulfomethyl-1,2,3,4-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (7-SACA) showed a good affinity for the active centre of PGA. The enzymatic acylation of these nuclei with R-methyl mandelate has been studied in order to evaluate different approaches for the enzymatic synthesis of cefonicid. The best results have been obtained in the acylation of 7-SACA. Cefonicid (8) was recovered from the reaction mixture as the disodium salt in 65% yield and about 95% of purity. Furthermore, through acylation of 7-ACA, a "one-pot" chemo-enzymatic synthesis was carried out starting from cephalosporin C using three enzymes in sequence: D-amino acid oxidase (DAO), glutaryl acylase (GA) and PGA. Cefonicid disodium salt was obtained in three steps, avoiding any intermediate purification, in 35% overall yield and about 94% purity. This approach presents several advantages compared with the classical chemical processes.
