56881-21-1

Basic information

• Product Name: ETHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE
• Synonyms: ETHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE;Ethyl 7-aminothieno[2,3-b]pyrazine-6-carboxylate, 97+%;7-Aminothieno[2,3-b]pyrazine-6-carboxylic acid ethyl ester
• CAS NO: 56881-21-1
• Molecular Formula: C₉H₉N₃O₂S
• Molecular Weight: 223.25166
• Mol File: 56881-21-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 119.5 °C
• Boiling Point: 390.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.429±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.65±0.40(Predicted)
• CAS DataBase Reference: ETHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE(56881-21-1)
• EPA Substance Registry System: ETHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE(56881-21-1)

Safety Data

• Hazardous Substances Data: 56881-21-1(Hazardous Substances Data)

Usage

General Description

ETHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE is a chemical compound with a molecular formula C11H10N2O2S. It is a heterocyclic molecule containing a thiophene ring and a pyrazine ring, as well as an ethyl ester group and an amino group. ETHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE is used in the pharmaceutical industry as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it valuable for the development of new drug candidates and biologically active compounds. Additionally, it has potential applications in organic synthesis and materials science due to its diverse bonding and reactivity.

Upstream product

• 623-51-8 ethyl 2-sulfanylacetate 
• 55557-52-3 2-chloro-3-cyanopyrazine 
• 74002-68-9 3-(phenylsulfonyl)pyrazine-2-carbonitrile 

Downstream Products

• 1351236-86-6 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-7-(methylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-99-4 7-amino-N-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)phenyl)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351238-82-8 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoic acid 
• 1351238-81-7 methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate 
• 1351236-84-4 7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-70-1 7-amino-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-59-6 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-7-(ethylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-58-5 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-7-(2,2,2-trifluoroacetamido)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-57-4 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-7-vinylthieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-56-3 7-cyano-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-54-1 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-7-methylthieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-53-0 7-bromo-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide 
• 59944-79-5 thieno[2,3-b]pyrazine-6-carboxylic acid 
• 59944-74-0 Chloro-7 thieno<2,3-b>pyrazine 

Relevant articles and documents

Synthesis and SAR Studies of 1 H-Pyrrolo[2,3- b]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors

Herein we report the synthesis, SAR, and biological evaluation of a series of 1H-pyrrolo[2,3-b]pyridine-2-carboxamide derivatives as selective and potent PDE4B inhibitors. Compound 11h is a PDE4B preferring inhibitor and exhibited acceptable in vitro ADME and significantly inhibited TNF-α release from macrophages exposed to pro-inflammatory stimuli (i.e., lipopolysaccharide and the synthetic bacterial lipopeptide Pam3Cys). In addition, 11h was selective against a panel of CNS receptors and represents an excellent lead for further optimization and preclinical testing in the setting of CNS diseases.

THIENO (2, 3B) PYRAZINE COMPOUNDS AS B-RAF INHIBITORS

The invention relates to compounds according to general Formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of cancer.

THIENO (2, 3B) PYRAZINE COMPOUNDS AS B - RAF INHIBITORS

The invention relates to compounds according to general Formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of cancer.