56882-00-9

Basic information

• Product Name: turbinaric acid
• Synonyms: turbinaric acid
• CAS NO: 56882-00-9
• Molecular Formula: C₂₇H₄₄O₂
• Molecular Weight: 400.643
• Mol File: 56882-00-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 523.3°Cat760mmHg
• Flash Point: 419.7°C
• Appearance: /
• Density: 0.919g/cm³
• Vapor Pressure: 2.36E-12mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: turbinaric acid(CAS DataBase Reference)
• NIST Chemistry Reference: turbinaric acid(56882-00-9)
• EPA Substance Registry System: turbinaric acid(56882-00-9)

Safety Data

• Hazardous Substances Data: 56882-00-9(Hazardous Substances Data)

Usage

General Description

Turbinaric acid is a naturally occurring chemical compound found in the leaves of several species of plants, including the Australian native plant Turbinaria lunata. It is a rare and unique compound with a polycyclic structure and is classified as a triterpenoid. Turbinaric acid has been studied for its potential pharmacological properties, including anti-inflammatory and antioxidant effects. It has also been investigated for its potential use in the development of new drugs and therapeutic agents. Additionally, turbinaric acid has been identified as a potent inhibitor of pro-inflammatory mediators, suggesting its potential as a natural anti-inflammatory agent. Overall, turbinaric acid is a promising compound with potential applications in pharmacology and medicine.

InChI:InChI=1/C27H44O2/c1-22(2)12-9-15-25(5)18-10-16-23(3)13-7-8-14-24(4)17-11-19-26(6)20-21-27(28)29/h12-14,18-19H,7-11,15-17,20-21H2,1-6H3,(H,28,29)/b23-13+,24-14+,25-18+,26-19+

Upstream product

• 14050-42-1 2,3-Oxidosqualene 
• 65746-05-6 squalene monobromohydrin: 3-bromo-2,6,10,15,19,23-hexamethyl-6,10,14,18,22-tetracosapentaen-2-ol (all E) 
• 111-02-4 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene 
• 54910-48-4 squalene 2,3(S)-oxide 
• 56882-05-4 (4E,8E,12E,16E)-4,8,13,17,21-pentamethyldocosa-4,8,12,16,20-pentaenal 

Downstream Products

• 1223521-28-5 3,3-dimethyl-7-oxo-6-[2-(4,8,13,17,21-pentamethyldocosa-4,8,12,16,20-pentaenoylamino)-2-phenylacetylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 
• 1158919-91-5 C₇₄H₉₃NO₁₅ 
• 1607425-20-6 C₅₉H₈₁N₄O₃⁽¹⁺⁾*Cl^(1-) 

Relevant articles and documents

Interaction of acyclovir and its squalenoyl-acyclovir prodrug with DMPC in monolayers at the air/water interface

Acyclovir has been conjugated to the acyclic isoprenoid chain of squalene to form the squalenoyl-acyclovir prodrug. Its interaction with biomembrane models constituted by dimyristoylphosphatidylcholine (DMPC) monolayers has been studied by employing the Langmuir-Blodgett technique. The aim of the work was to gain information on the interaction of these compounds with phospholipid membranes. DMPC/acyclovir or squalenoyl-acyclovir prodrug mixed monolayers have been prepared at increasing molar fractions of the compound and the isotherm mean molecular area/surface pressure has been registered at 10 and 37 °C. Results reveal that the squalenoyl moiety enhances the affinity of acyclovir for the biomembrane model.

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnetite surface involving hydrophobic-hydrophobic interactions between the metallic core and the squalene moieties. The system was characterized in terms of hydrodynamic radius, zeta potential, shape and drug loading capacity. On the whole, the stealth-like shell stabilized the suspension in aqueous media, though allowing the release of the doxorubicin loaded in therapeutic range. The cytotoxicity profile on cancer (HCT116) cell line and in vitro drug uptake were evaluated both with and without an external magnetic field used as targeting agent and uptake promoter, displaying that magnetic targeting implies advantageous therapeutic effects, that is amplified drug uptake and increased anticancer activity throughout the tumor mass.

Trisnorsqualene Alcohol, a Potent Inhibitor of Vertebrate Squalene Epoxidase

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OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF

Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

VITAMIN C COMPLEXES

A complex formed of at least one molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or a derivative covalently bonded with at least one hydrocarbon radical with formula (A) as follows: wherein: ?-m 1=1, 2, 3, 4, 5 or 6; ?-m 2=0, 1, 2, 3, 4, 5 or 6; and represents the site of the bond with the molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or derivative. Formula (I)