56882-52-1

Basic information

• Product Name: ETHYL 2,4-DICHLOROBENZOATE
• Synonyms: RARECHEM AL BI 0019;ETHYL 2,4-DICHLOROBENZOATE;Benzoic acid, 2,4-dichloro-, ethyl ester
• CAS NO: 56882-52-1
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.06
• Mol File: 56882-52-1.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 272.8 °C at 760 mmHg
• Flash Point: 111.8 °C
• Appearance: /
• Density: 1.305 g/cm³
• Vapor Pressure: 0.00595mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: ETHYL 2,4-DICHLOROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DICHLOROBENZOATE(56882-52-1)
• EPA Substance Registry System: ETHYL 2,4-DICHLOROBENZOATE(56882-52-1)

Safety Data

• Hazardous Substances Data: 56882-52-1(Hazardous Substances Data)

Usage

General Description

Ethyl 2,4-dichlorobenzoate is a chemical compound that is often used as a pesticide or herbicide for controlling unwanted plant growth. It is a colorless, crystalline solid with a slightly sweet odor. This chemical is derived from benzoic acid and has two chlorine atoms attached to the benzene ring. It is commonly used in commercial products for agricultural and industrial applications. When applied, ethyl 2,4-dichlorobenzoate acts as a selective herbicide that targets specific types of plants while remaining safe for others. However, it is important to handle this chemical with caution and to follow safety guidelines while using it.

InChI:InChI=1/C9H8Cl2O2/c1-2-13-9(12)7-4-3-6(10)5-8(7)11/h3-5H,2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 50-84-0 2,4 dichlorobenzoic acid 
• 141-52-6 sodium ethanolate 

Downstream Products

• 184877-74-5 OTUB₂-COV-19 
• 183368-35-6 2-(chloromethyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole 
• 1464794-57-7 (E)-2-((2-benzo[d][1,3]dioxol-5-yl)vinyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole 
• 1464794-39-5 (E)-2-(2,4-dichlorophenyl)l-5-(3,4,5-trimethoxystyryl)-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis, spectral analysis, antibacterial, antifungal, antioxidant and hemolytic activity studies of some new 2,5-disubstituted-1,3,4-oxadiazoles

Series of 1,3,4-oxadiazole derivatives (5a–5g and 5h, 5i) were synthesized and characterized by FT-IR, 1H NMR, 13C NMR and HR-MS spectral analysis. All the target compounds were screened for their in vitro antibacterial activity against two Gram-negative bacterial strains namely Escherichia coli (MTCC 405) and Salmonella typhi (MTCC 3224) and two Gram-positive bacterial strains namely Bacillus subtilis (MTCC 1790) and Bacillus megaterium (MTCC 1684) and antifungal activity against Aspergillus niger (MTCC 282), Rhizopus oryzae (MTCC 262), Penicillium chrysogenum (MTCC 974), and Candida albicans (MTCC 183) fungal strains. The synthesized compounds exhibited significant antibacterial and antifungal potential. Three compounds (5e, 5f and 5g) have shown higher antibacterial activity with very low MIC values comparable to streptomycin. According to the SAR study, the antibacterial efficacy can be intensified by substituting fluoro and methyl substituents at the para position in acid hydrazide. The synthesized compounds were also screened for % radical scavenging activity by OH and DPPH assay and found to be good antioxidant agents. Besides, the hemolytic study revealed that the synthesized 1,3,4-oxadiazoles possessed negligible cytotoxicity compared with the standard.

Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles

A series of novel steroidal derivatives with a substituted 1,3,4-oxadiazole structure was designed and synthesized, and the target compounds were evaluated for their insecticidal activity against five aphid species. Most of the tested compounds exhibited potent insecticidal activity against Eriosoma lanigerum (Hausmann), Myzus persicae, and Aphis citricola. Compounds 20g and 24g displayed the highest activity against E. lanigerum, showing LC50 values of 27.6 and 30.4 μg/mL, respectively. Ultrastructural changes in the midgut cells of E. lanigerum were detected by transmission electron microscopy, indicating that these steroidal oxazole derivatives might exert their insecticidal activity by destroying the mitochondria and nuclear membranes in insect midgut cells. Furthermore, a field trial showed that compound 20g exhibited effects similar to those of the positive controls chlorpyrifos and thiamethoxam against E. lanigerum, reaching a control rate of 89.5% at a dose of 200 μg/mL after 21 days. We also investigated the hydrolysis and metabolism of the target compounds in E. lanigerum by assaying the activities of three insecticide-detoxifying enzymes. Compound 20g at 50 μg/mL exhibited inhibitory action on carboxylesterase similar to the known inhibitor triphenyl phosphate. The above results demonstrate the potential of these steroidal oxazole derivatives to be developed as novel pesticides.

Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

Toward the search of new antibacterial agents to control methicillin-resistant Staphylococcus aureus (MRSA), a class of new norfloxacin-1,3,4-oxadiazole hybrids were designed and synthesized. Antibacterial activities against drug-sensitive bacteria S. aureus and clinical drug resistant isolates of MRSA were evaluated. Compound 5k exhibited excellent antibacterial activities against S. aureus (MIC: 2 μg/mL) and MRSA1–3 (MIC: 0.25–1 μg/mL). The time-kill kinetics demonstrated that compound 5k had an advantage over commonly used antibiotics vancomycin in killing S. aureus and MRSA. Moreover, compound 5k could inhibit the bacteria and destroy their membranes in a short time, and showed very low cytotoxicity to NRK-52E cells. Some interesting structure-activity relationships (SARs) were also discussed. These results indicated that these norfloxacin-1,3,4-oxadiazole hybrids could be further developed into new antibacterial agents against MRSA.