56886-07-8

Basic information

• Product Name: Propanehydrazonoyl chloride, N-(4-methoxyphenyl)-2-oxo-
• CAS NO: 56886-07-8
• Molecular Formula: C10H11ClN2O2
• Molecular Weight: 226.663
• Mol File: 56886-07-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Propanehydrazonoyl chloride, N-(4-methoxyphenyl)-2-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanehydrazonoyl chloride, N-(4-methoxyphenyl)-2-oxo-(56886-07-8)
• EPA Substance Registry System: Propanehydrazonoyl chloride, N-(4-methoxyphenyl)-2-oxo-(56886-07-8)

Safety Data

• Hazardous Substances Data: 56886-07-8(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 1694-29-7 3-chloropentane-2,4-dione 
• 4346-59-2 para-methoxyphenyldiazonium chloride 

Downstream Products

• 177574-09-3 1-[(4-chlorophenyl)thio]-1-[(4-methoxyphenyl) hydrazono]-2-propanone 

Relevant articles and documents

Bis-heterocycles. Part I: Tetrahydro-5,5′- bi(1,2,4-triazin-6-ones)

Selected sets of tetrahydro-5,5′-bi(1,2,4-triazines) (1-3) appended with acetyl, benzoyl, and ester moieties at C-3 position and N-1 (p-substituted)phenyl ring have been prepared and characterized by spectral (IR, NMR, MS) data and X-ray diffraction for c

Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents

In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.

Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones

A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.