5692-35-3

Basic information

• Product Name: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI)
• Synonyms: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI);3,5-dimethylbenzamide
• CAS NO: 5692-35-3
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Product Categories: AMIDE
• Mol File: 5692-35-3.mol
• Article Data: 22

Chemical Properties

• Melting Point: 135-135.5 °C(Solv: water (7732-18-5))
• Boiling Point: 231.8 °C at 760 mmHg
• Flash Point: 94 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0.061mmHg at 25°C
• Refractive Index: 1.55
• PKA: 16.22±0.50(Predicted)
• CAS DataBase Reference: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI)(5692-35-3)
• EPA Substance Registry System: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI)(5692-35-3)

Safety Data

• Hazardous Substances Data: 5692-35-3(Hazardous Substances Data)

Usage

General Description

Benzamide, 3,5-dimethyl- (7CI,8CI,9CI) is a chemical compound with the molecular formula C9H11NO. It is a derivative of benzamide and consists of a benzene ring with an amide group and two methyl groups attached at the 3 and 5 positions. This chemical is widely used in the pharmaceutical and chemical industries as a building block for the synthesis of various compounds. It is also utilized in organic synthesis and research as a reagent and intermediate. The properties and uses of benzamide, 3,5-dimethyl- make it a valuable and versatile compound in various applications.

InChI:InChI=1/C9H11NO/c1-6-3-7(2)5-8(4-6)9(10)11/h3-5H,1-2H3,(H2,10,11)

Upstream product

• 108-24-7 acetic anhydride 
• 72569-75-6 N-(2-pyridylmethyl)-3,5-dimethylbenzamide N-Oxide 
• 108-67-8 1,3,5-trimethyl-benzene 
• 556-96-7 5-bromo-1,3-xylene 
• 1202932-70-4 N-methoxy-3,5-dimethylbenzamide 
• 201230-82-2 carbon monoxide 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 22445-42-7 3,5-dimethylbenzonitrile 
• 5779-95-3 3,5-dimethylbenzaldehyde 
• 72583-99-4 4-(3,5-Dimethylbenzoylaminomethyl)pyridine 1-Oxide 
• 108462-88-0 (E)-ethyl 2-cyano-3-(4-pyridyl)-3-(3,5-dimethylbenzoylamino)acrylate 
• 79988-88-8 N-<(α-hydroxy)-4-pyridylmethyl>-3,5-dimethylbenzamide 
• 64-17-5 ethanol 
• 79988-86-6 N-<(α-acetoxy)-4-pyridylmethyl>-3,5-dimethylbenzamide 

Downstream Products

• 156092-23-8 (-)-(4S)-4,5-Dihydro-2-(3',5'-dimethylphenyl)-4-isopropyloxazole 
• 108-69-0 3,5-dimethylaminoaniline 
• 172369-18-5 N,3,5-trimethylbenzamide 
• 13319-70-5 3,5-dimethylbenzophenone 
• 57312-28-4 C₁₁H₁₅NO 
• 124289-23-2 3-(bromomethyl)-5-methylbenzonitrile 

Relevant articles and documents

Mechanism of Acid-Catalyzed Proton Exchange in Amides

The kinetics of acid-catalyzed proton exchange in a series of primary amides were studied by NMR.The saturation-transfer method measures independently all six rate constants for exchange among sites HE, HZ, and solvent OH (usually et

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.

Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles

The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chemical nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles.