56949-94-1

Basic information

• Product Name: Benzenepropanoic acid, a-ethenyl-b-hydroxy-, methyl ester
• CAS NO: 56949-94-1
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol File: 56949-94-1.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-ethenyl-b-hydroxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-ethenyl-b-hydroxy-, methyl ester(56949-94-1)
• EPA Substance Registry System: Benzenepropanoic acid, a-ethenyl-b-hydroxy-, methyl ester(56949-94-1)

Safety Data

• Hazardous Substances Data: 56949-94-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 3724-55-8 methyl but-3-enoate 
• 1117-71-1 methyl 4-bromocrotonate 
• 1117-71-1 methyl-4-bromo-2-butenoate 
• 186581-53-3 diazomethane 
• 69637-13-4 2-[hydroxy(phenyl)methyl]but-3-enoic acid 
• 3724-65-0 2-butenoic acid 
• 119582-47-7 tert-butyl((1-methoxybuta-1,3-dien-1-yl)oxy)dimethylsilane 
• 623-43-8 crotonic acid methyl ester 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 71-43-2 benzene 
• 29943-38-2 2-methoxycarbonyl-1-methylethyl phenyl sulfide 
• 107-93-7 (E)-but-2-enoic acid 

Downstream Products

• 154073-05-9 methyl 2-phenyl-2,5-dihydro-3-furancarboxylate 
• 72853-48-6 (E)-Methyl 2-(phenylhydroxymethyl)-2-butenoate 

Relevant articles and documents

Synthesis of α-alkenyl-β-hydroxy adducts by α-addition of unprotected 4-bromocrotonic acid and amides with aldehydes and ketones by chromium(II)-mediated reactions

The regioselective and diastereoselective chromium(II)-mediated reactions of 4-bromocrotonic acid or amides with aldehydes and ketones can proceed without the need to protect protic sites to generate the respective α-alkenyl-β-hydroxy adducts, i.e. formally the addition of the α-anion of a carboxylic acid or amide to an oxo-compound is featured.

Oxazaborolidinone-promoted vinylogous mukaiyama aldol reactions

δ-Hydroxy-α,β-unsaturated carbonyl compounds were prepared in one step via the vinylogous Mukaiyama aldol reactions with O,O-silyl ketene acetals. Isopropyl alcohol as additive and tryptophane-based B-phenyloxazaborolidinone were required for obtaining th

An efficient approach to (E)-β-methyl Baylis-Hillman adducts via indium-mediated allylation of aldehydes in aqueous media

A new method has been developed for the synthesis of (E)-β-methyl Baylis-Hillman adducts with high E-Z (>93%) selectivity in modest to good yields. The process consists of two steps: an indium-mediated allylation reaction and a simple base-catalyzed isomerization step. Various aldehydes were allylated with allyl bromides using indium under very mild conditions in aqueous media. The allylation reactions of aromatic and aliphatic aldehydes were largely accelerated by the presence of HCl.