56951-36-1

Basic information

• Product Name: 2-phenyl-4-pyrrolidino-butyronitrile
• Synonyms: 2-phenyl-4-pyrrolidino-butyronitrile
• CAS NO: 56951-36-1
• Molecular Weight: 214.31
• Mol File: 56951-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4-pyrrolidino-butyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-pyrrolidino-butyronitrile(56951-36-1)
• EPA Substance Registry System: 2-phenyl-4-pyrrolidino-butyronitrile(56951-36-1)

Safety Data

• Hazardous Substances Data: 56951-36-1(Hazardous Substances Data)

Upstream product

• 5050-41-9 N-(2-chloroethyl)-pyrrolidine 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 56951-03-2 1-(4-chlorophenyl)-4-[2-(1-pyrrolidino)-ethyl]-1,4-dihydro-2H-isoquinoline-3-one 
• 1236131-24-0 (Z)-2,3-dipropyl-4-phenyl-6-(pyrrolidin-1-yl)hex-2-enenitrile 
• 1236131-39-7 (Z)-3-isopropyl-2-methyl-4-phenyl-6-(pyrrolidin-1-yl)hex-2-enenitrile 
• 1236131-35-3 (Z)-2-isopropyl-3-methyl-4-phenyl-6-(pyrrolidin-1-yl)hex-2-enenitrile 

Relevant articles and documents

Heteroatom-directed alkylcyanation of alkynes

Alkanenitriles having a heteroatom such as nitrogen, oxygen, and sulfur at the γ-position are found to add across alkynes stereo-and regioselectively by nickel/Lewis acid catalysis to give highly substituted acrylonitriles. The heteroatom functionalities likely coordinate to the nickel center to make oxidative addition of the C-CN bonds of the alkyl cyanides kinetically favorable, forming a five-membered nickelacycle intermediate and, thus, preventing β-hydride elimination to allow the alkylcyanation reaction.