56968-26-4Relevant articles and documents
Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents
Archana, Archana
, p. 199 - 203 (2021/01/25)
Reaction of piperazine with chloroacetylchloride in dry acetone yield compound 1, which on reaction with hydrazine hydrate yielded compound 2, which was further reacted with various substituted phenylisothiocyanates in absolute alcohol to afford compounds
Synthesis of novel Azol-β-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies
Mermer, Arif,Bayrak, Hacer,?irin, Yakup,Emirik, Mustafa,Demirba?, Neslihan
, p. 279 - 287 (2019/04/25)
This study reports the synthesis, biological investigation and molecular docking of novel β-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. The synthesized compounds were evaluated for in vitro antiurease activity and antiox
Piperazine clubbed with 2-azetidinone derivatives suppresses proliferation, migration and induces apoptosis in human cervical cancer HeLa cells through oxidative stress mediated intrinsic mitochondrial pathway
Khanam, Rashmin,Kumar, Raj,Hejazi, Iram Iqbal,Shahabuddin, Syed,Meena, Ramovatar,Jayant, Vikrant,Kumar, Prabhat,Bhat, Abdul Roouf,Athar, Fareeda
, p. 113 - 131 (2018/01/27)
Abstract: Piperazine scaffolds or 2-azetidinone pharmacophores have been reported to show anti-cancer activities and apoptosis induction in different types of cancer cells. However, the mechanistic studies involve in induction of apoptosis addressing thes
