57-44-3 Usage
Description
Barbital, also known as Veronal, is a barbiturate that acts as an agonist at GABAA receptors, inducing central nervous system depression. It is a white crystalline powder or solid with a bitter taste and is odorless. Barbital is stable in air and soluble in hot water, alcohol, ether, acetone, and ethyl acetate. It has been used as a sedative to treat insomnia and seizures in human and veterinary medicine. In the United States, it is regulated as a Schedule IV compound and is intended for research and forensic applications.
Uses
Used in Pharmaceutical Industry:
Barbital is used as a sedative for the treatment of insomnia and seizures. It acts on GABAA receptors to induce central nervous system depression, providing relief from sleep disorders and seizure conditions.
Used in Veterinary Medicine:
Barbital is used as a sedative in veterinary medicine to treat insomnia and seizures in animals, similar to its application in human medicine.
Used in Research and Forensic Applications:
As an analytical reference material and a certified reference material, Barbital is used in research and forensic applications for the study and analysis of its properties and effects.
Used in Drug Formulations:
Barbital has been used in various drug formulations under different brand names such as Dormileno, Escoderm, Hypnogene, Hypnox, Lidor, Megal, Plexonal, Somnytic tablets, Verinogen, Verodon, Veroletten, Verolitten, and Veronigen. These formulations were primarily used as hypnotics or sleeping aids.
World Health Organization (WHO)
Barbital is a long-acting barbiturate which is controlled under
Schedule IV of the 1971 Convention on Psychotropic Substances. See WHO
comment for barbiturates.
(Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV),
, , 1971)
Safety Profile
Poison by ingestion, intravenous,intraperitoneal, and subcutaneous routes. Ingestion causespsychological effects in humans. Mutation data reported.When heated to decomposition it emits toxic fumes ofNOx. An hypnotic andsedative.
Purification Methods
Crystallise barbital from water or EtOH and dry it in a vacuum over P2O5. [Beilstein 24 III/IV 1901.]
Check Digit Verification of cas no
The CAS Registry Mumber 57-44-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 57-44:
(4*5)+(3*7)+(2*4)+(1*4)=53
53 % 10 = 3
So 57-44-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13)
57-44-3Relevant articles and documents
Synthesis, crystal structures, DNA binding and cytotoxicity of two novel platinum(II) complexes containing 2-(hydroxymethyl)pyridine and pyridine-2-carboxylate ligands
Icsel, Ceyda,Yilmaz, Veysel T.,Golcu, Aysegul,Ulukaya, Engin,Buyukgungor, Orhan
, p. 2117 - 2122 (2013)
Two new platinum(II) complexes, trans-[Pt(2-mpy)2] ·4H2O (1) and [PtCl(2-pyc)(2-hmpy)]·H2O (2), where 2-hmpy = 2-(hydroxymethyl)pyridine, 2-mpy = deprotonated 2-hmpy and 2-pyc = pyridine-2-carboxylate, have been synthesized and characterized by elemental analysis, IR, NMR, and X-ray crystallography. The DNA binding affinities of these complexes for Fish Sperm DNA (FS-DNA) were investigated using fluorescence, viscosity, thermal denaturation and gel electrophoresis measurements. Fluorescence analysis indicates that complex 1 binds to DNA by a single intercalative mechanism, while complex 2 exhibits two types of interactions such as intercalation and covalent binding. Gel electrophoresis assay demonstrates ability of the complexes to cleavage the supercoiled pBR322 plasmid DNA. The in vitro cytotoxicities of both complexes were preliminarily evaluated and the cytotoxicity of complex 1 against the human lung cancer cells (H1299) is similar to oxaliplatin, but higher than transplatin and carboplatin.
Composition of matter having bioactive properties
-
, (2008/06/13)
Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.
Photochemical reactions of barbituric acids
Aoyama, Hiromu,Hatori, Hiroaki
, p. 3781 - 3788 (2007/10/02)
Photochemical reaction of barbital (1a) and its derivatives gave Norrish type II reaction products. Their photochemical reactivities is discussed in comparison with those of other nitrogen-containing carbonyl compounds.
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