570-54-7 Usage
Description
3-beta,17-alpha-dihydroxy-5-alpha-pregnan-20-one, also known as 5α-Pregnan-3β,17α-diol-20-one, is a derivative of pregnenolone, a steroid hormone that plays a crucial role in the synthesis of various other steroid hormones, including progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. It functions as a prohormone and has been identified as a GABAA antagonist, which contributes to its neuromodulatory effects. Additionally, it is known to increase neurogenesis in the hippocampus and modulate the activity of cytochrome P 450-3A.
Uses
Used in Pharmaceutical Industry:
3-beta,17-alpha-dihydroxy-5-alpha-pregnan-20-one is used as a pharmaceutical agent for its neuromodulatory properties. As a GABAA antagonist, it can help in the treatment of neurological disorders and conditions related to the central nervous system. Its ability to increase neurogenesis in the hippocampus suggests potential applications in the treatment of neurodegenerative diseases and cognitive impairments.
Used in Steroid Hormone Research:
In the field of endocrinology and steroid hormone research, 3-beta,17-alpha-dihydroxy-5-alpha-pregnan-20-one serves as a valuable compound for studying the biosynthesis and regulation of various steroid hormones. Its role as a prohormone makes it an essential component in understanding the complex interplay between different hormones and their effects on the body.
Used in Drug Metabolism Studies:
3-beta,17-alpha-dihydroxy-5-alpha-pregnan-20-one is used as a research tool in drug metabolism studies, particularly in the investigation of cytochrome P 450-3A, a major enzyme involved in the metabolism of various drugs and substances. Understanding its modulation of this enzyme can provide insights into drug interactions and the development of more effective therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 570-54-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 0 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 570-54:
(5*5)+(4*7)+(3*0)+(2*5)+(1*4)=67
67 % 10 = 7
So 570-54-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H34O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h14-18,23-24H,4-12H2,1-3H3/t14-,15-,16+,17-,18-,19-,20-,21-/m0/s1
570-54-7Relevant articles and documents
5 α-pregnan-20-ones and 5-pregnen-20-ones and related compounds
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, (2008/06/13)
Compounds of the formulae: STR1 useful as anti-obesity, anti-diabetic, anti-coronary and hypolipidemic agents.
The Reaction of Enols with Superoxide Anion Radicals: Preparation of Tertiary α-Ketols
Betancor, Carmen,Francisco, Cosme G.,Freire, Raimundo,Suarez, Ernesto
, p. 947 - 948 (2007/10/02)
Pregnan-20-ones (1) and (4) and 3β-hydroxy-5α-cholestan-6-one (7) react with KO2 and 18-crown-6 benzene solution and under an oxygen atmosphere at 6-7 deg C to give the corresponding α-hydroperoxides (2), (5), and (8) which after treatment with Ph3P gives α-ketols (3), (6), and (9) in good yields.
REARRANGEMENT SPINAL DU DIMETHYL-4,4 EPOXY-6α,20α(5α)ANDROSTANE AVEC LE TRICHLORURE DE BORE
Fetizon, Marcel,Sozzi, Georges
, p. 61 - 68 (2007/10/02)
A backbone rearrangement of 4,4 dimethyl 6α,20α epoxy (5α)androstane with BCl3 is described.The structures of the resulting compounds have been elucidated either by synthesis from 3β-acetoxy (5α)pregnane 20-one, or by X rays diffraction.
