57018-10-7

Basic information

• Product Name: Phenol, 2-bromo-6-chloro-4-methyl-
• Synonyms: Phenol,2-bromo-6-chloro-4-methyl;2-bromo-6-chloro-4-methyl-phenol;2-bromo-4-methyl-6-chlorophenol;2-Brom-6-chlor-4-methyl-phenol;5-Chlor-3-brom-4-hydroxy-toluol
• CAS NO: 57018-10-7
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.481
• Mol File: 57018-10-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 30 °C
• Boiling Point: 127-128 °C(Press: 3 Torr)
• Density: 1.674±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Phenol, 2-bromo-6-chloro-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-bromo-6-chloro-4-methyl-(57018-10-7)
• EPA Substance Registry System: Phenol, 2-bromo-6-chloro-4-methyl-(57018-10-7)

Safety Data

• Hazardous Substances Data: 57018-10-7(Hazardous Substances Data)

Upstream product

• 106-44-5 p-cresol 
• 6640-27-3 2-chloro-p-cresol 
• 6627-55-0 2-bromo-p-cresol 

Downstream Products

• 1849-76-9 3-bromo-5-chloro-4-hydroxybenzaldehyde 
• 227766-67-8 2-(2-bromo-6-chloro-4-methyl-phenoxy)-6-chloro-4-methoxy-4-methyl-cyclohexa-2,5-dienone 
• 857831-58-4 2,3-dibromo-6-chloro-4-methyl-phenol 
• 408328-16-5 2,3,5-tribromo-6-chloro-4-methyl-phenol 
• 60468-61-3 2-chloro-4-methyl-6-nitrophenol 
• 57018-05-0 O,O-dimethyl O-2-bromo-4-methyl-6-chlorophenyl phosphorothioate 
• 61306-22-7 Acetic acid 3-bromo-5-chloro-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester 
• 859821-73-1 2-amino-3-bromo-6-chloro-4-methyl-phenol 
• 869085-33-6 2-bromo-6-chloro-4-methylphenyl 2-propenyl ether 
• 61305-77-9 2-Brom-6-chlor-4-hydroxy-4-methyl-cyclohexa-2,5-dienon 
• 61306-41-0 2-Bromo-6-chloro-4-methoxy-4-methyl-cyclohexa-2,5-dienone 

Relevant articles and documents

Design, synthesis and structure–activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands

A new series of carboxyaryl-substituted phenylalanines was designed, synthesized and pharmacologically characterized in vitro at native rat ionotropic glutamate receptors as well as at cloned homomeric kainate receptors GluK1–GluK3. Among them, six compounds bound to GluK1 receptor subtypes with reasonable affinity (Kivalues in the range of 4.9–7.5?μM). A structure–activity relationship (SAR) for the obtained series, focused mainly on the pharmacological effect of structural modifications in the 4- and 5-position of the phenylalanine ring, was established. To illustrate the results, molecular docking of the synthesized series to the X-ray structure of GluK1 ligand binding core was performed. The influence of individual substituents at the phenylalanine ring for both the affinity and selectivity at AMPA, GluK1 and GluK3 receptors was analyzed, giving directions for future studies.