57018-12-9Relevant articles and documents
A scalable and green one-minute synthesis of substituted phenols
Elumalai, Vijayaragavan,Hansen, J?rn H.
, p. 40582 - 40587 (2020/11/18)
A mild, green and highly efficient protocol was developed for the synthesis of substituted phenols via ipso-hydroxylation of arylboronic acids in ethanol. The method utilizes the combination of aqueous hydrogen peroxide as the oxidant and H2O2/HBr as the reagent under unprecedentedly simple and convenient conditions. A wide range of arylboronic acids were smoothly transformed into substituted phenols in very good to excellent yields without chromatographic purification. The reaction is scalable up to at least 5 grams at room temperature with one-minute reaction time and can be combined in a one-pot sequence with bromination and Pd-catalyzed cross-coupling to generate more diverse, highly substituted phenols.
Concise total synthesis of (±)-aspidospermidine via an oxidative Hosomi-Sakurai process
Sabot, Cyrille,Guerard, Kimiaka C.,Canesi, Sylvain
supporting information; experimental part, p. 2941 - 2943 (2009/12/01)
A concise total synthesis of (±)-aspidospermidine has been achieved in twelve steps from inexpensive 4-ethylphenol, based on an oxidative Hosomi-Sakurai reaction via the concept of "aromatic ring umpolung".
