57027-72-2

Basic information

• Product Name: Benzene, 1-(2-methylpropoxy)-4-nitro-
• CAS NO: 57027-72-2
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Mol File: 57027-72-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-methylpropoxy)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-methylpropoxy)-4-nitro-(57027-72-2)
• EPA Substance Registry System: Benzene, 1-(2-methylpropoxy)-4-nitro-(57027-72-2)

Safety Data

• Hazardous Substances Data: 57027-72-2(Hazardous Substances Data)

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 100-00-5 4-chlorobenzonitrile 
• 350-46-9 4-Fluoronitrobenzene 
• 100-02-7 4-nitro-phenol 
• 513-38-2 Isobutyl iodide 
• 636-98-6 p-nitrobenzene iodide 
• 78-77-3 Isobutyl bromide 
• 1124-31-8 potassium 4-nitrophenolate 

Downstream Products

• 288249-46-7 N-(3-cyano-4-isobutoxyphenyl)-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288249-32-1 N-(3-cyano-4-isobutoxyphenyl)-1,5-dimethylpyrazole-4-carboxamide 
• 1418313-48-0 ethyl N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)-5-methylpyrazol-4-ylcarbonyl]glycine 
• 288249-69-4 N-(3-cyano-4-neopentyloxyphenyl)-N-[1-(4-fluorophenyl)-5-methylpyrazol-4-ylcarbonyl]glycine 
• 288249-47-8 N-(3-cyano-4-isobutoxyphenyl)-1-(4-fluorophenyl)-5-hydroxypyrazole-4-carboxamide 
• 288249-48-9 N-(3-cyano-4-neopentyloxyphenyl)-1-(4-fluorophenyl)-N,3-dimethylpyrazole-4-carboxamide 
• 288251-94-5 5-amino-2-isobutoxybenzyl cyanide 
• 288249-40-1 N-(3-cyano-4-neopentyloxyphenyl)-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288251-95-6 2-isobutoxy-5-nitrobromobenzene 
• 5198-04-9 4-(2-methylpropoxy)aniline 

Relevant articles and documents

2-Fluoro-5-nitrophenyldiazonium: A Novel Sanger-Type Reagent for the Versatile Functionalization of Alcohols

As a novel Sanger-type reagent, 2-fluoro-5-nitrophenyldiazonium tetrafluoroborate enabled the versatile functionalization of primary and secondary aliphatic alcohols. Based on a mild nucleophilic aromatic substitution of the fluorine atom under unprecedented, base-free conditions, the diazonium unit on the aromatic core of the resulting aryl-alkyl ether could be employed for such diverse transformations as radical C?H activation and cyclization, as well as palladium catalyzed cross-coupling reactions.

Synthesis and antimicrobial studies of new antibacterial azo-compounds active against staphylococcus aureus and listeria monocytogenes

Some novel (phenyl-diazenyl)phenols (4a–m) were designed and synthesized to be evaluated for their antibacterial activity. Starting from an active previously-synthesized azobenzene chosen as lead compound, we introduced some modifications and optimization of the structure, in order to improve solubility and drug conveyance. Structures of all newly-synthesized compounds were confirmed by 1H nuclear magnetic resonance (NMR), mass spectrometry, and UV-Vis spectroscopy. Antibacterial activity of the new compounds was tested with the dilution method against the bacteria strains Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa PAO1. All the compounds were selectively active against Gram-positive bacteria. In particular, compounds 4d, 4h, and 4i showed the highest activity against S. aureus and Listeria monocytogenes, reaching remarkable MIC100 values of 4 μg/mL and 8 μg/mL. The relationship between antimicrobial activity and compound structure has suggested that the presence of hydroxyl groups seems to be essential for antimicrobial activity of phenolic compounds.

4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES

The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.