57053-02-8

Basic information

• Product Name: diMethyl 2-aMinoisophthalate
• Synonyms: diMethyl 2-aMinoisophthalate;1,3-dimethyl 2-aminobenzene-1,3-dicarboxylate;dimethyl 2-aminobenzene-1,3-dioate
• CAS NO: 57053-02-8
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.19864
• Mol File: 57053-02-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 102-103 °C
• Boiling Point: 309.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.19±0.10(Predicted)
• CAS DataBase Reference: diMethyl 2-aMinoisophthalate(CAS DataBase Reference)
• NIST Chemistry Reference: diMethyl 2-aMinoisophthalate(57053-02-8)
• EPA Substance Registry System: diMethyl 2-aMinoisophthalate(57053-02-8)

Safety Data

• Hazardous Substances Data: 57053-02-8(Hazardous Substances Data)

Usage

General Description

DiMethyl 2-aMinoisophthalate is a chemical compound with the molecular formula C10H13NO4. It is also known as 2-amino-1,3-benzenedicarboxylic acid dimethyl ester and is commonly used as an intermediate in the synthesis of various pharmaceutical and fine chemical compounds. diMethyl 2-aMinoisophthalate is a derivative of isophthalic acid and contains two methyl groups and an amino group attached to the benzene ring. DiMethyl 2-aMinoisophthalate is a white crystalline solid with a molecular weight of 211.21 g/mol and is soluble in various organic solvents. It is also used in the production of dyes, pigments, and polymers due to its versatile chemical properties.

Upstream product

• 67-56-1 methanol 
• 99-31-0 5-aminoisophthalic acid 
• 39622-79-2 2-aminoisophthalic acid 
• 57052-99-0 dimethyl 2-nitroisophthalate 
• 21161-11-5 2-nitroisophthalic acid 
• 81-20-9 2,6-dimethylnitrobenzene 

Downstream Products

• 1322091-04-2 C₂₀H₂₆N₂O₇ 

Relevant articles and documents

V-shaped chiral carboxylic acid ligand, preparation method and application thereof

The invention discloses a V-shaped chiral carboxylic acid ligand L-H2, relates to the technical field of synthetic chemistry and coordination chemistry, and also provides a preparation method of the ligand and an application of the ligand in assembling chiral complexes. The preparation method has the beneficial effects that the prepared V-shaped chiral carboxylic acid ligand is cheap in synthesis raw materials, simple in preparation method and suitable for large-scale preparation, has proper ligand rigidity and special coordination guidance and is beneficial to overcoming the flexibility of a framework of amino acid and the flexibility of a coordination mode. Therefore, a complex material with a chiral structure is easy to assemble.

Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants

A chemical genetic approach is presented to covalently target a unique lipid binding pocket in the protein kinase p38α, whose function is not yet known. Based on a series of cocrystal structures, a library of 2-arylquinazolines that were decorated with electrophiles were designed and synthesized to covalently target tailored p38α mutants containing artificially introduced cysteine residues. Matching protein–ligand pairs were identified by MS analysis and further validated by MS/MS studies and protein crystallography. The covalent ligands that emerged from this approach showed excellent selectivity towards a single p38α mutant and will be applicable as suitable probes in future studies of biological systems to dissect the function of the lipid pocket by means of pharmacological perturbations.

Large yet flexible N-heterocyclic carbene ligands for palladium catalysis

A straightforward and scalable eight-step synthesis of new N-heterocyclic carbenes (NHCs) has been developed from inexpensive and readily available 2-nitro-m-xylene. This process allows for the preparation of a novel class of NHCs coined ITent ("Tent" for "tentacular") of which the well-known IMes (N,N′-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene), IPr (N,N′-bis(2,6-di(2-propyl)phenyl)imidazol-2-ylidene) and IPent (N,N′-bis(2,6-di(3-pentyl)phenyl)imidazol-2-ylidene) NHCs are the simplest and already known congeners. The synthetic route was successfully used for the preparation of three members of the ITent family: IPent (N,N′-bis(2,6- di(3-pentyl)phenyl)imidazol-2-ylidene), IHept (N,N′-bis(2,6-di(4-heptyl) phenyl)imidazol-2-ylidene) and INon (N,N′-bis(2,6-di(5-nonyl)phenyl) imidazol-2-ylidene). The electronic and steric properties of each NHC were studied through the preparation of both nickel and palladium complexes. Finally the effect of these new ITent ligands in Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-couplings was investigated. Tentacular NHCs: A straightforward, scalable eight-step synthesis of N-heterocyclic carbenes (NHCs) has been developed using inexpensive and readily available 2-nitro-m-xylene, allowing the preparation of a class of NHCs designated ITent ("Tent" for "tentacular"). The electronic and steric properties of each NHC were studied through the preparation of both nickel and palladium complexes, and the effect of these new ITent ligands in Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-couplings was investigated.