5707-59-5

Basic information

• Product Name: Benzenepropanoic acid, a-ethylidene-
• CAS NO: 5707-59-5
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol File: 5707-59-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-ethylidene-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-ethylidene-(5707-59-5)
• EPA Substance Registry System: Benzenepropanoic acid, a-ethylidene-(5707-59-5)

Safety Data

• Hazardous Substances Data: 5707-59-5(Hazardous Substances Data)

Upstream product

• 1024-41-5 benzyl tosylate 
• 620-05-3 iodomethylbenzene 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 114779-92-9 rac-2-benzyl-3-butenoic acid 
• 139592-86-2 methyl 2-benzylbut-3-enoate 
• 55791-06-5 benzyl mesylate 
• 100-52-7 benzaldehyde 
• 123986-72-1 2-benzyl-3-hydroxy-butyric acid 
• 859200-22-9 benzyl-vinyl-malonic acid diethyl ester 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 91344-46-6 2-benzylidene-but-3-enoic acid 
• 145293-84-1 (Z)-2-benzylbut-2-enoic acid ethyl ester 
• 3246-27-3 tert-butyl crotonate 

Downstream Products

• 1026652-72-1 (S)-2-[(S)-2-(3-Acetylsulfanyl-2-benzyl-butyrylamino)-hexanoylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 1026256-85-8 (S)-2-[(S)-2-(3-Acetylsulfanyl-2-benzyl-butyrylamino)-3-methyl-butyrylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 1026520-19-3 (3-Acetylsulfanyl-2-benzyl-butyrylamino)-acetic acid methyl ester 
• 26197-64-8 (E)-2-benzylidenebutanoic acid 

Relevant articles and documents

The studies on the chemoenzymatic synthesis of 2-benzyl-3-butenoic acid

The studies on the chemoenzymatic synthesis of 2-benzyl-3-butenoic acid 3 were performed. The alkylation of dienolates derived from the crotonic and vinylacetic acids with different types of alkylating agents was examined. In all cases the inseparable mixture of isomeric acids 3 and 4 were obtained. Chemoselective enzymatic esterification of those mixtures provides ester 6 in 86% yield as a single product without double bond isomerization. None common method can be used for its hydrolysis since under basic conditions only isomeric acid 5 is formed. To overcome this limitation enzyme catalysed hydrolysis process was design. This protocol afforded isomerically pure acid 3 in 98% yield.