57078-98-5 Usage
Description
4-MALEIMIDOBUTYRIC ACID, also known as 4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid, is a chemical compound that contains a maleimide group and a terminal carboxylic acid. It is a white solid and is known for its ability to form covalent bonds with thiol groups in proteins, making it a versatile reagent in various applications.
Uses
Used in Biochemistry and Molecular Biology:
4-MALEIMIDOBUTYRIC ACID is used as a short crosslinking reagent for the modification of thiol groups in proteins. This allows for the connection of biomolecules with a thiol, which is crucial in various research and diagnostic applications.
Used in Pharmaceutical Industry:
4-MALEIMIDOBUTYRIC ACID is used as a modification reagent for thiol groups in proteins. Its ability to form stable amide bonds with primary amine groups in the presence of activators, such as EDC or HATU, makes it a valuable tool in drug development and the creation of novel therapeutic agents.
Used in Chemical Synthesis:
As a part of the maleimide derivatives family, 4-MALEIMIDOBUTYRIC ACID is used in the synthesis of various chemical compounds, contributing to the development of new materials and products in different industries.
Used in Research and Development:
4-MALEIMIDOBUTYRIC ACID is used as an MTS & Sulfhydryl active reagent, enabling researchers to study the interactions between biomolecules and their potential applications in various fields, including medicine, biotechnology, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 57078-98-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,0,7 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 57078-98:
(7*5)+(6*7)+(5*0)+(4*7)+(3*8)+(2*9)+(1*8)=155
155 % 10 = 5
So 57078-98-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO4/c10-6-3-4-7(11)9(6)5-1-2-8(12)13/h3-4H,1-2,5H2,(H,12,13)
57078-98-5Relevant articles and documents
Skeletal Analogues of UCS1025A and B by Cyclization of Maleimides: Synthesis and Biological Activity
Ibbotson, Lewis T.,Christensen, Kirsten E.,Genov, Miroslav,Pretsch, Alexander,Pretsch, Dagmar,Moloney, Mark G.
, p. 396 - 400 (2022/02/10)
Application of a direct ring-closing approach which exploits an intramolecular aldol reaction with a ketene silyl acetal onto a remote imide function leading to the core skeleton of UCS1025A and B effectively provides access to small library of substituted analogues; of interest is their complete lack of antibacterial activity against MRSA (Gram+) and E. coli (Gram-) bacterial strains.
CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS
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Page/Page column 201-202, (2021/10/30)
Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.
A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS
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Page/Page column 270, (2021/01/23)
Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.
