57101-34-5Relevant articles and documents
Process development of a potent glucosylceramide synthase inhibitor
Cooper, Christopher G.F.,Lee, Edward R.,Silva, Richard A.,Bourque, Andre J.,Clark, Scott,Katti, Sanjeev,Nivorozhkin, Vitaly
, p. 1090 - 1097 (2012)
An economic, scalable process for the production of glucosylceramide synthase (GCS) inhibitor 7 has been developed. Herein we report a three-step synthesis to aldehyde 4 with high yield and purity that employs the selective cleavage of an endocyclic C-O b