57144-64-6

Basic information

• Product Name: methyl 2-benzyl-2-methylbutanoate
• Synonyms: methyl 2-benzyl-2-methylbutanoate
• CAS NO: 57144-64-6
• Molecular Weight: 206.285
• Mol File: 57144-64-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 2-benzyl-2-methylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-benzyl-2-methylbutanoate(57144-64-6)
• EPA Substance Registry System: methyl 2-benzyl-2-methylbutanoate(57144-64-6)

Safety Data

• Hazardous Substances Data: 57144-64-6(Hazardous Substances Data)

Upstream product

• 868-57-5 methyl 2-methylbutanoate 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 595-37-9 2,2-dimethylbutyric acid 
• 67-56-1 methanol 
• 57144-65-7 2-(phenylmethyl)-2-methylbutanoic acid 

Downstream Products

• 1541196-47-7 C₂₆H₃₂N₂O 
• 1613146-07-8 3-ethyl-3-methyl-4-phenyl-1-(8-quinolinyl)-2-azetidinone 
• 1613146-06-7 3-benzyl-3-ethyl-1-(8-quinolinyl)-2-azetidinone 
• 1534433-42-5 2-benzyl-2-(4-methoxybenzyl)-N-(quinolin-8-yl)butanamide 
• 57144-65-7 2-(phenylmethyl)-2-methylbutanoic acid 

Relevant articles and documents

Nickel-catalyzed site-selective alkylation of unactivated C(sp 3)-H bonds

The direct alkylation of unactivated sp3 C-H bonds of aliphatic amides was achieved via nickel catalysis with the assist of a bidentate directing group. The reaction favors the C-H bonds of methyl groups over the methylene C-H bonds and tolerates various functional groups. Moreover, this reaction shows a predominant preference for sp3 C-H bonds of methyl groups via a five-membered ring intermediate over the sp2 C-H bonds of arenes in the cyclometalation step.

Copper-catalyzed site-selective intramolecular amidation of unactivated C(sp3)-H bonds

The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp3 C-H bond functionalization process. The reaction favors predominantly the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds. Moreover, a preference for activating sp3 C-H bonds of β-methyl groups, via a five-membered ring intermediate, over the aromatic sp2 C-H bonds was also observed in the cyclometalation step. Additionally, sp3 C-H bonds of unactivated secondary sp3 C-H bonds could be functionalized by favoring the ring carbon atoms over the linear carbon atoms. Getting ahead on tams: The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp 3 C-H bond functionalization process to deliver β-lactams. The reaction favors the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds, as well as aromatic C(sp2)-H bonds and unactivated secondary C(sp3)-H bonds of rings.

Indaneacetic acid derivatives

This invention provides new compounds of formula I, STR1 wherein R1 is lower alkyl, R2 is hydrogen or lower alkyl, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, R5 is hydrogen, chlorine or lower alkyl, and each of R6 and R7 is hydrogen, or, when R5 is hydrogen, R6 may also be chlorine or lower alkyl, and R7 chlorine or lower alkyl, Useful as anti-phlogistic and anti-arthritic agents.