57180-99-1

Basic information

• Product Name: Propanedioic acid, [(4-cyanophenyl)methyl]-, diethyl ester
• CAS NO: 57180-99-1
• Molecular Formula: C15H17NO4
• Molecular Weight: 275.304
• Mol File: 57180-99-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(4-cyanophenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(4-cyanophenyl)methyl]-, diethyl ester(57180-99-1)
• EPA Substance Registry System: Propanedioic acid, [(4-cyanophenyl)methyl]-, diethyl ester(57180-99-1)

Safety Data

• Hazardous Substances Data: 57180-99-1(Hazardous Substances Data)

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 126989-04-6 p-Cyanbenzyliden-malonsaeurediethylester 
• 17201-43-3 4-cyanobenzyl bromide 
• 105-53-3 diethyl malonate 

Downstream Products

• 1094200-66-4 monoethyl (4-cyanobenzyl)malonate 
• 1211547-66-8 C₂₅H₃₇NO₅Si 
• 122497-11-4 2-ethenyl-6-<4-hydroxy-3-(1,4,7,10-tetra-azacyclotridecan-11-yl-benzyl)carbamoylmethoxymethyl>pyridine 
• 122497-09-0 12-(4-aminomethylbenzyl)-1,4,7,10-tetraazacyclotridecane 
• 124659-34-3 {3-[4-(Acetylamino-methyl)-benzyl]-5,9-bis-ethoxycarbonylmethyl-1,5,9-triaza-cyclododec-1-yl}-acetic acid ethyl ester 
• 124659-35-4 3-para-Aminomethylbenzyl-1,5,9-triazacyclododecane-N,N',N-triacetic acid 
• 124659-21-8 4-[2,4-Dioxo-9-(toluene-4-sulfonyl)-1,5,9-triaza-cyclododec-3-ylmethyl]-benzonitrile 
• 124659-22-9 4-[9-(Toluene-4-sulfonyl)-1,5,9-triaza-cyclododec-3-ylmethyl]-benzylamine 
• 124659-33-2 N-[4-(1,5,9-Triaza-cyclododec-3-ylmethyl)-benzyl]-acetamide 
• 127603-42-3 4-(1,5,9-Triaza-cyclododec-3-ylmethyl)-benzylamine 
• 112936-13-7 2-ethenyl-6-<4-hydroxy-3-(1,4,8,11-tetra-azacyclotetradecan-5-yl)benzylcarbamoylmethoxymethyl>pyridine 
• 112936-12-6 6-(4-aminomethylbenzyl)-1,4,8,11-tetra-azacyclotetradecane 
• 129227-92-5 12-(4-cyanobenzyl)-1,4,7,10-tetraazacyclotridecan-11,13-dione 
• 112936-14-8 6-(4-cyanobenzyl)-1,4,8,11-tetra-azacyclotetradecan-5,7-dione 

Relevant articles and documents

HYDRIDE TRANSFER IN THE REDUCTION OF SUBSTITUTED BENZYLIDENE MALONIC DIESTERS BY COENZYME NAD(P)H MODEL

The reduction of substituted benzylidene malonic diesters by 1-benzyl-1,4-dihydronicotinamide (BNAH) is catalyzed by magnesium perchlorate.Kinetic isotope effects studies show that the C(4)-H bond cleavage in BNAH is involved in the rate determining step.Spectroscopic investigations have revealed that the ternary complex is formed in the ground state while complexation of substrate with magnesium ion is rate enhancing.

Overturning established chemoselectivities: Selective reduction of arenes over malonates and cyanoacetates by photoactivated organic electron donors

The prevalence of metal-based reducing reagents, including metals, metal complexes, and metal salts, has produced an empirical order of reactivity that governs our approach to chemical synthesis. However, this reactivity may be influenced by stabilization of transition states, intermediates, and products through substrate-metal bonding. This article reports that in the absence of such stabilizing interactions, established chemoselectivities can be overthrown. Thus, photoactivation of the recently developed neutral organic superelectron donor 5 selectively reduces alkyl-substituted benzene rings in the presence of activated esters and nitriles, in direct contrast to metal-based reductions, opening a new perspective on reactivity. The altered outcomes arising from the organic electron donors are attributed to selective interactions between the neutral organic donors and the arene rings of the substrates.

EP2/4 AGONISTS

EP2/4 compounds having improved dual pharmacological activity are described. The uniqueness of using EP2/4 dual agonists resides in their ability to modify both uveoscleral outflow via the ciliary muscle and conventional outflow via trabecular meshwork and Schlemm's canal all in the same treatment paradigm. The compounds can be employed for the treatment of glaucoma and ocular hypertension. Formula (I).