57189-64-7Relevant articles and documents
Metal triflate promoted synthesis of naphthalenes
Chan, Chieh-Kai,Wang, Heui-Sin,Tsai, Yu-Lin,Chang, Meng-Yang
, p. 29321 - 29329 (2017)
A synthetic route to derive the skeleton of naphthalenes starting with isovanillin is described with modest total yields via the key transformation of metal triflate-mediated intramolecular benzannulation of o-formyl or o-benzoyl allylbenzenes in MeNO2 at rt.
Fused Catechol Ethers from Gold(I)-Catalyzed Intramolecular Reaction of Propargyl Ethers with Acetals
Pati, Kamalkishore,Dos Passos Gomes, Gabriel,Harris, Trevor,Alabugin, Igor V.
supporting information, p. 928 - 931 (2016/03/15)
Selective gold(I)-catalyzed rearrangement of aromatic methoxypropynyl acetals leads to fused catechol ethers (1,2-dialkoxynapthalenes) in excellent yields. Furthermore, this process extends to the analogous heterocyclic and aliphatic substrates. Alkyne activation triggers nucleophilic addition of the acetal oxygen that leads to an equilibrating mixture of oxonium ions of similar stability. This mixture is "kinetically self-sorted" via a highly exothermic cyclization. Selective formation of 1,2-dialkoxy naphthalenes originates from chemoselective aromatization of the cyclic intermediate via 1,4-elimination of methanol.
N-(2-phenyl-4-piperidinybutyl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamides and their use as neurokinin 1 (NK1) and/or neurokinin 2 (NK2) receptor antagonists
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, (2008/06/13)
Compounds of formula (I), wherein R2is a 5,6,7,8-tetrahydronaphth-1-yl group which may be substituted (the remaining groups defined herein), and pharmaceutical compositions containing the compounds and methods of using the compounds in the treatment of a condition where antagonism of the NK1 and/or NK2 receptors is beneficial.
