57229-41-1 Usage
Description
N-(9-Hydroxy-9H-fluoren-2-yl)acetamide is a metabolite produced by the liver from carcinogens such as 2-acetamidofluorene (A158535). It can be activated by liver homogenate and is known to form potent frameshift mutagens. N-(9-Hydroxy-9H-fluoren-2-yl)acetamide is significant in the study of liver carcinogenesis and is utilized as a reference material for its identification or quantitation.
Uses
Used in Research and Development:
N-(9-Hydroxy-9H-fluoren-2-yl)acetamide is used as a research compound for studying the mechanism of liver carcinogenesis. Its role in the activation of carcinogens and formation of mutagens provides valuable insights into the processes leading to liver cancer.
Used in Analytical Chemistry:
In the field of analytical chemistry, N-(9-Hydroxy-9H-fluoren-2-yl)acetamide serves as a reference material. It is employed for the identification and quantitation of this specific metabolite, which is crucial in understanding its impact on liver carcinogenesis and potentially developing targeted therapies or preventive measures.
Used in Pharmaceutical Industry:
N-(9-Hydroxy-9H-fluoren-2-yl)acetamide is used as a compound of interest in the pharmaceutical industry. Its properties and interactions with biological systems may lead to the development of new drugs or therapies aimed at preventing or treating liver cancer.
Used in Toxicology:
In toxicology, N-(9-Hydroxy-9H-fluoren-2-yl)acetamide is used as a model compound to study the effects of carcinogens on the liver. Understanding its activation and mutagenicity can help in assessing the risks associated with exposure to similar compounds and inform safety guidelines and regulations.
Safety Profile
Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits toxic fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 57229-41-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,2,2 and 9 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 57229-41:
(7*5)+(6*7)+(5*2)+(4*2)+(3*9)+(2*4)+(1*1)=131
131 % 10 = 1
So 57229-41-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO2/c1-9(17)16-10-6-7-12-11-4-2-3-5-13(11)15(18)14(12)8-10/h2-8,15,18H,1H3,(H,16,17)
57229-41-1Relevant articles and documents
COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF FLUORENE
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Paragraph 0418, (2019/05/15)
This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.
