5724-05-0Relevant articles and documents
Synthesis of Antitricyclic Morpholine Derivatives through Iodine(III)-Mediated Intramolecular Umpolung Cycloaddition of Olefins
Deng, Qingfu,Feng, Yangyang,Xiong, Ruimei,Xiong, Yan,Yang, Chenglin,Zhang, Xiaohui
, p. 4500 - 4506 (2020/04/09)
A (diacetoxyiodo)benzene-mediated intramolecular cycloaddition of olefins to construct tricyclic morpholines is presented. A series of substituted tricyclic morpholines were obtained in one-step simple operation under mild conditions, and the NMR studies
C(alkenyl)-H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis
Liu, Mingyu,Yang, Pusu,Karunananda, Malkanthi K.,Wang, Yanyan,Liu, Peng,Engle, Keary M.
supporting information, p. 5805 - 5813 (2018/05/14)
A catalytic method to prepare highly substituted 1,3-dienes from two different alkenes is described using a directed, palladium(II)-mediated C(alkenyl)-H activation strategy. The transformation exhibits broad scope across three synthetically useful substrate classes masked with suitable bidentate auxiliaries (4-pentenoic acids, allylic alcohols, and bishomoallylic amines) and tolerates internal nonconjugated alkenes, which have traditionally been a challenging class of substrates in this type of chemistry. Catalytic turnover is enabled by either MnO2 as the stoichiometric oxidant or co-catalytic Co(OAc)2 and O2 (1 atm). Experimental and computational studies were performed to elucidate the preference for C(alkenyl)-H activation over other potential pathways. As part of this effort, a structurally unique alkenylpalladium(II) dimer was isolated and characterized.
Aminothiocarbamate-catalyzed asymmetric bromolactonization of 1,2-disubstituted olefinic acids
Tan, Chong Kiat,Zhou, Ling,Yeung, Ying-Yeung
, p. 2738 - 2741 (2011/06/26)
An efficient and enantioselective bromolactonization of 1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst has been developed, resulting in the formation of δ-lactones containing two chiral centers with up to 99% yield, 95% ee.
