57245-31-5

Basic information

• Product Name: 8-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: 8-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE;8-CHLORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE;TIMTEC-BB SBB014314
• CAS NO: 57245-31-5
• Molecular Formula: C₈H₆ClNO₂
• Molecular Weight: 183.59
• Mol File: 57245-31-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 362.652 °C at 760 mmHg
• Flash Point: 173.126 °C
• Appearance: /
• Density: 1.393 g/cm³
• PKA: 11.89±0.20(Predicted)
• CAS DataBase Reference: 8-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE(57245-31-5)
• EPA Substance Registry System: 8-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE(57245-31-5)

Safety Data

• Hazardous Substances Data: 57245-31-5(Hazardous Substances Data)

Usage

General Description

8-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE is a chemical compound with the formula C8H4ClNO2. It is a synthetic organic compound that belongs to the class of benzoxazinones. 8-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE is often used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and pharmaceutical products. It possesses a chlorine atom and a benzoxazinone ring structure, making it a valuable building block for the creation of novel chemical compounds with potential biological activity. Its precise applications and uses may vary depending on the specific research or manufacturing needs.

Upstream product

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Downstream Products

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Relevant articles and documents

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

A series of potential new 5-HT2 receptor scaffolds based on a simplification of the clinically studied, 5-HT2CR agonist vabicaserin, were designed. An in vivo feeding assay early in our screening process played an instrumental part in the lead identification process, leading us to focus on a 6,5,7-tricyclic scaffold. A subsequent early SAR investigation provided potent agonists of the 5-HT2C receptor that were highly selective in both functional and binding assays, had good rat PK properties and that significantly reduced acute food intake in the rat.

Morpholine derivatives

The disclosure relates to new morpholine derivatives which possess antidepressant activity, to processes for the manufacture of said derivatives and to pharmaceutical compositions containing them. Typical of the morpholine derivatives disclosed is 2-(4H-2