57248-14-3

Basic information

• Product Name: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE
• Synonyms: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE;2,5-DICHLOROTHIOPHENE-3-CARBOXYLICHLORIDE
• CAS NO: 57248-14-3
• Molecular Formula: C₅HCl₃OS
• Molecular Weight: 215.48
• Mol File: 57248-14-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 125°C 15mm
• Flash Point: 101.5°C
• Appearance: /
• Density: 1.667g/cm³
• Vapor Pressure: 0.0306mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE(57248-14-3)
• EPA Substance Registry System: 2,5-DICHLOROTHIOPHENE-3-CARBONYL CHLORIDE(57248-14-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 57248-14-3(Hazardous Substances Data)

Usage

Description

2,5-Dichlorothiophene-3-carbonyl chloride is an organic compound characterized by its chlorine atoms at the 2nd and 5th positions on the thiophene ring and a carbonyl chloride group attached to the 3rd position. It is a versatile chemical intermediate with potential applications in various industries due to its unique chemical structure and reactivity.

Uses

Used in Chemical Synthesis:
2,5-Dichlorothiophene-3-carbonyl chloride is used as a reactant for the preparation of insecticidal hydrazine derivatives. Its unique chemical structure allows it to react with other compounds to form new molecules with insecticidal properties, which can be utilized in the agricultural industry to protect crops from pests and improve yield.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,5-Dichlorothiophene-3-carbonyl chloride can be used as a building block for the synthesis of various pharmaceutical compounds. Its reactivity and functional groups make it a valuable intermediate for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2,5-Dichlorothiophene-3-carbonyl chloride can also be employed in the agrochemical industry for the development of new pesticides and herbicides. Its chemical properties enable it to be a key component in the synthesis of compounds with effective pest control and weed management capabilities.
Used in Dye and Pigment Industry:
Due to its chemical structure, 2,5-Dichlorothiophene-3-carbonyl chloride can be used in the dye and pigment industry for the synthesis of novel dyes and pigments with unique color properties and improved stability. This can lead to the development of new products with enhanced performance in various applications, such as textiles, plastics, and coatings.

InChI:InChI=1/C5HCl3OS/c6-3-1-2(4(7)9)5(8)10-3/h1H

Upstream product

• 36157-41-2 2,5-dichlorothiophene-3-carboxylic acid 

Downstream Products

• 98215-53-3 2,5-Dichloro-thiophene-3-carboxylic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide 
• 334918-23-9 (2,5-dichloro-thiophen-3-yl)-(1-trityl-1H-imidazol-4-yl)-methanol 
• 334918-28-4 (2,5-dichloro-thiophen-3-yl)-(1-trityl-1H-imidazol-4-yl)-methanone 
• 1246249-59-1 2-{4-[4-(2,5-dichlorothiophene-3-carbonyl)piperazin-1-yl]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one 
• 1418130-85-4 2,5-dichloro-N-(2-hydroxy-4-methyl-phenyl)thiophene-3-carboxamide 

Relevant articles and documents

Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer

Over the past few decades, an increasing variety of molecular chaperones have been investigated for their role in tumorigenesis and as potential chemotherapeutic targets; however, the 60 kDa Heat Shock Protein (HSP60), along with its HSP10 co-chaperone, have received little attention in this regard. In the present study, we investigated two series of our previously developed inhibitors of the bacterial homolog of HSP60/10, called GroEL/ES, for their selective cytotoxicity to cancerous over non-cancerous colorectal cells. We further developed a third “hybrid” series of analogs to identify new candidates with superior properties than the two parent scaffolds. Using a series of well-established HSP60/10 biochemical screens and cell-viability assays, we identified 24 inhibitors (14%) that exhibited > 3-fold selectivity for targeting colorectal cancer over non-cancerous cells. Notably, cell viability EC50 results correlated with the relative expression of HSP60 in the mitochondria, suggesting a potential for this HSP60-targeting chemotherapeutic strategy as emerging evidence indicates that HSP60 is up-regulated in colorectal cancer tumors. Further examination of five lead candidates indicated their ability to inhibit the clonogenicity and migration of colorectal cancer cells. These promising results are the most thorough analysis and first reported instance of HSP60/10 inhibitors being able to selectively target colorectal cancer cells and highlight the potential of the HSP60/10 chaperonin system as a viable chemotherapeutic target.

(THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS

A dual H1 inverse agonist/5-HT2A receptor antagonist of the formula: [Formula I], its uses, and methods for its preparation are described.

Facile synthesis of 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4- ones

Interaction between 2,5-dichlorothiophene-3-carbonyl isothiocyanate, accessible via 2,5-dichlorothiophene-3-carbonyl chloride, and model heterocyclic amines produced the respective 2,5-dichloro-N-(substituted aminocarbonothioyl) thiophene-3-carboxamides. Upon heating, the deprotonated form of the latter underwent intramolecular cyclization to deliver the corresponding 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones. The structures of these new bicyclic derivatives and their acyclic precursors are based on microanalytical and spectral (IR, MS, and NMR) data.