57252-83-2

Basic information

• Product Name: 3-methylcyclobutane-1-carboxylic acid
• Synonyms: 3-methylcyclobutane-1-carboxylic acid;3-Methylcyclobutylcarboxylic acid;3-Methylcyclobutanecarboxylic acid;Cyclobutanecarboxylic acid, 3-methyl-
• CAS NO: 57252-83-2
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.15
• Mol File: 57252-83-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 194℃
• Flash Point: 88℃
• Appearance: /
• Density: 1.105
• Vapor Pressure: 0.196mmHg at 25°C
• Refractive Index: 1.478
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.81±0.40(Predicted)
• CAS DataBase Reference: 3-methylcyclobutane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methylcyclobutane-1-carboxylic acid(57252-83-2)
• EPA Substance Registry System: 3-methylcyclobutane-1-carboxylic acid(57252-83-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-52
• Safety Statements: 26
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 57252-83-2(Hazardous Substances Data)

Usage

Description

3-Methylcyclobutane-1-carboxylic acid is an organic compound characterized by its unique cyclobutane ring structure with a methyl group and a carboxylic acid functional group. It is known for its reactivity and potential applications in various industries due to its chemical properties.

Uses

Used in Polymer Industry:
3-Methylcyclobutane-1-carboxylic acid is used as a reactant for the preparation of alternating copolymers through ring-opening metathesis polymerization (ROMP) of methylcyclobutene and dimethylcyclobutene. This process allows for the creation of novel polymers with specific properties, such as enhanced strength, flexibility, or chemical resistance, which can be utilized in various applications, including automotive, aerospace, and consumer products.
The use of 3-methylcyclobutane-1-carboxylic acid in the polymer industry is significant because it enables the development of advanced materials with tailored properties for specific applications. The ROMP process involving this acid allows for precise control over the polymer structure, leading to improved performance and functionality in the final products.

InChI:InChI=1/C6H10O2/c1-4-2-5(3-4)6(7)8/h4-5H,2-3H2,1H3,(H,7,8)

Upstream product

• 20939-62-2 3-Methyl-1,1-cyclobutandicarbonsaeure-diaethylester 
• 28148-04-1 1,3-dibromo-2-methylpropane 
• 105-53-3 diethyl malonate 
• 939768-58-8 benzyl 3-methylenecyclobutane-1-carboxylate 
• 15760-36-8 3-methylenecyclobutane-1-carboxylic acid 
• 3280-19-1 1-methoxycarbonyl-3-methyl-2-(N-piperidinyl)cyclobutane 
• 89533-69-7 3-Methyl-cyclobut-1-en-1-carbonsaeure 
• 31603-86-8 3-methyl-cyclobutanecarbonitrile 
• 6974-77-2 1-bromo-3-chloro-2-methyl propane 
• 996-82-7 sodium diethylmalonate 
• 57252-84-3 3-Methyl-1,1-cyclobutandicarbonsaeure 
• 15760-35-7 3-methylenecyclobutanecarbonitrile 

Downstream Products

• 89381-06-6 3-Methyl-cyclobutylamin-⁽¹⁾ 
• 24070-81-3 (3-methylcyclobutyl)methanol 
• 1297137-23-5 1-(3-methylcyclobutyl)-4-[(4-nitrophenyl)sulfonyl]-2-piperazinone 
• 1297137-22-4 N₁-(3-methylcyclobutyl)-N₂-[(4-nitrophenyl)sulfonyl]glycinamide 
• 71473-97-7 3,N,N-Trimethyl-carbamoyl-cyclobutan 
• 1192-08-1 3-methylcyclobutan-1-one 
• 121609-52-7 1-(4'-Bromo-biphenyl-4-yl)-2-(3-methyl-cyclobutyl)-ethanone 
• 121609-44-7 (3-Methyl-cyclobutyl)-acetic acid 
• 101268-23-9 (3-methylcyclobutyl)methyl 4-methylbenzenesulfonate 
• 89896-76-4 3-Methyl-1-acetyl-cyclobutan 
• 99769-39-8 3-methyl-cyclobutanecarboxylic acid ethyl ester 

Relevant articles and documents

Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors

The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

General Synthesis of Methyl- and Dimethyl-cyclobutanes from Simple 1,3-Diols by Phase Transfer Catalysis

A general method is described for the preparation of methyl- and dimethyl-cyclobutanes from simple 1,3-diols.The key steps of the procedure are a phase transfer catalysed ring closure and the transformation of a carboxyl group to a methyl group.Phase transfer catalysis provides good yields in the synthesis of the cyclobutane skeleton.

Synthesis and liquid crystal properties of compounds incorporating cyclobutane, spiroheptane and dispirodecane rings

A number of esters of structure (I) incorporating the cyclobutane, spiroheptane, or dispirodecane rings has been prepared using a diethyl malonate synthesis.Strict comparison of the liquid crystal behaviour amongst the three classes containing a terminal cyano-substituent was not possible because both the cyclobutanes and dispirodecanes are mixtures of cis- and trans-isomers; the spiroheptanes are racemic systems.Using preparative hplc, it was however possible to isolate the pure cis- and trans-isomers of two of the cyano-substituted cyclobutane esters (I; R = alkyl, -X- = --, Y = CN).From the physical data and the results for the corresponding spiroheptane esters, conclusions regarding the effects of these ring systems on liquid crystal behaviour were obtained.The pure cis- and trans-isomers of the cyclobutane ester (I, R = C3H7, -X- = --, Y = CN) have been assessed for the trends in both order parameter and viscosity with temperature; the results support the idea that idea that the trans-cyclobutane ring adopts a more planar conformation at higher temperatures.Keywords: cyclobutane- and related spiro-systems, cis-/trans-isomerism, order parameter, briefringence, viscosity, structure/property relations.