572922-90-8

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(methoxycarbonyl)cyclopropyl]amino]carbonyl]- 4-[(4-nitrobenzoyl)oxy]-, 1,1-dimethylethyl ester, (2S,4S)-
• CAS NO: 572922-90-8
• Molecular Formula: C24H29N3O9
• Molecular Weight: 503.509
• Mol File: 572922-90-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(methoxycarbonyl)cyclopropyl]amino]carbonyl]- 4-[(4-nitrobenzoyl)oxy]-, 1,1-dimethylethyl ester, (2S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(methoxycarbonyl)cyclopropyl]amino]carbonyl]- 4-[(4-nitrobenzoyl)oxy]-, 1,1-dimethylethyl ester, (2S,4S)-(572922-90-8)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(methoxycarbonyl)cyclopropyl]amino]carbonyl]- 4-[(4-nitrobenzoyl)oxy]-, 1,1-dimethylethyl ester, (2S,4S)-(572922-90-8)

Safety Data

• Hazardous Substances Data: 572922-90-8(Hazardous Substances Data)

Upstream product

• 62-23-7 4-nitro-benzoic acid 
• 572922-91-9 (2S,4S)-4-Hydroxy-2-((1R,2S)-1-methoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 572922-89-5 (2S,4R)-4-hydroxy-2-[(1R,2S)-1-methoxycarbonyl-2-vinylcyclopropylcarbamoyl]pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 300832-84-2 ciluprevir 
• 912291-98-6 4-Nitro-benzoic acid (3S,5S)-1-((S)-2-cyclopentyloxycarbonylamino-non-8-enoyl)-5-((1R,2R)-1-methoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-pyrrolidin-3-yl ester 
• 912291-94-2 4-nitro-benzoic acid 1-(2-cyclopentyloxycarbonylamino-non-8-enoyl)-5-(1-methoxycarbonyl-2-vinylcyclopropylcarbamoyl)-pyrrolidin-3-yl ester 
• 912291-95-3 (1S,4R,6S,7Z,14S,18S)-14-cyclopentyloxycarbonylamino-18-(4-nitro-benzoyloxy)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.0^4,6]nonadec-7-ene-4-carboxylic acid methyl ester 
• 782479-05-4 (1S,4R,6S,7Z,14S,18S)-18-(4-bromo-benzenesulfonyloxy)-14-cyclopentyloxycarbonylamino-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.0^4,6]nonadec-7-ene-4-carboxylic acid methyl ester 

Relevant articles and documents

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of Formula (I): wherein B, R3, L0, L1, R2, Rc and R1 are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection. In particular, the present invention provides novel peptide analogs, pharmaceutical compositions containing such analogs, and uses of these analogs in the treatment of HCV infection

Hepatitis C inhibitor peptide analogs

Compounds of formula (I): wherein R1, R2, R3, R4, R5, Y, n and m are as defined herein. The compounds are useful as inhibitors of HCV NS3 protease.

Macrocyclic peptides active against the hepatitis C virus

Compounds of formula I: wherein R1 is hydroxy or NHSO2R1A wherein R1A is (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl}, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O(C1-6)alkyl, amido, amino or phenyl, or R1A is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O(C1-6)alkyl, amido, amino or phenyl; R2 is (C5-6)cycloalkyl and R3 is cyclopentyl; or a pharmaceutically acceptable salt thereof, useful as inhibitors of the HCV NS3 protease.