5730-02-9

Basic information

• Product Name: N-benzylheptan-1-amine
• Synonyms: Benzenemethanamine, N-heptyl-
• CAS NO: 5730-02-9
• Molecular Formula: C₁₄H₂₃N
• Molecular Weight: 205.3391
• Mol File: 5730-02-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 287.7°C at 760 mmHg
• Flash Point: 115.9°C
• Density: 0.892g/cm³
• Vapor Pressure: 0.00244mmHg at 25°C
• Refractive Index: 1.495
• PKA: 9.93±0.19(Predicted)
• CAS DataBase Reference: N-benzylheptan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzylheptan-1-amine(5730-02-9)
• EPA Substance Registry System: N-benzylheptan-1-amine(5730-02-9)

Safety Data

• Hazardous Substances Data: 5730-02-9(Hazardous Substances Data)

Upstream product

• 111-68-2 1-Heptylamine 
• 108-88-3 toluene 
• 55917-04-9 N-benzyl-7-methylazepan-2-one 
• 766-08-5 methylphenylsilane 
• 906433-55-4 1-benzyl-2-ethylpiperidine 
• 111-71-7 heptanal 
• 100-46-9 benzylamine 
• 140-11-4 Benzyl acetate 
• 100-52-7 benzaldehyde 
• 111-70-6 n-heptan1ol 
• 55-21-0 benzamide 
• 6728-31-0 (Z)-4-heptenal 
• 58979-19-4 N-(phenylmethylene)-1-heptanamine 

Downstream Products

• 111-68-2 1-Heptylamine 
• 143632-83-1 N-heptylbenzamide 

Relevant articles and documents

BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3and hydride transfer from formic acid.

Cine-Silylative Ring-Opening of α-Methyl Azacycles Enabled by the Silylium-Induced C-N Bond Cleavage

Described herein is the development of a borane-catalyzed cine-silylative ring-opening of α-methyl azacycles. This transformation involves four-step cascade processes: (i) exo-dehydrogenation of alicyclic amine, (ii) hydrosilylation of the resultant enamine, (iii) silylium-induced cis-β-amino elimination to open the ring skeleton, and (iv) hydrosilylation of the terminal olefin. The present borane catalysis also works efficiently for the C-N bond cleavage of acyclic tertiary amines. On the basis of experimental and computational studies, the silicon atom was elucidated to play a pivotal role in the β-amino elimination step.

Reductive amination of aldehydes and amines with an efficient Pd/NiO catalyst

By applying a simple Pd/NiO catalyst, the reductive amination of amines and aldehydes can progress efficiently under mild reaction conditions, and 24 substituted amines with different structures were synthesized with up to 98% isolated yields.