57308-51-7 Usage
Clinical Use
#N/A
Metabolism
Levodopa is rapidly decarboxylated by the enzyme
aromatic l-amino acid decarboxylase, mostly in the gut,
liver, and kidney, to dopamine, which is metabolised
in turn, principally to dihydroxyphenylacetic acid
(DOPAC) and homovanillic acid (HVA). Other routes
of metabolism include O-methylation, transamination,
and oxidation, producing a variety of minor metabolites
including noradrenaline and 3-O-methyldopa; the latter
may accumulate in the CNS due to its relatively long
half-life.About 80% of an oral dose of levodopa is excreted in the
urine within 24 hours, mainly as dihydroxyphenylacetic
and homovanillic acids. Only small amounts of levodopa
are excreted unchanged in the faeces.Carbidopa inhibits the peripheral decarboxylation of
levodopa to dopamine. It is rapidly excreted in the urine
both unchanged and in the form of metabolites.
Check Digit Verification of cas no
The CAS Registry Mumber 57308-51-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,3,0 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 57308-51:
(7*5)+(6*7)+(5*3)+(4*0)+(3*8)+(2*5)+(1*1)=127
127 % 10 = 7
So 57308-51-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O4.C9H11NO4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h2-4,12-14H,5,11H2,1H3,(H,15,16);1-2,4,6,11-12H,3,10H2,(H,13,14)/t10-;6-/m00/s1
