57339-57-8

Basic information

• Product Name: 6-bromoquinolin-8-amine
• Synonyms: 6-bromoquinolin-8-amine;6-Bromo-8-quinolinamine;8-QuinolinaMine, 6-broMo-;6-BroMo-8-aMinoquinoline
• CAS NO: 57339-57-8
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.07
• Mol File: 57339-57-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 78 °C
• Boiling Point: 370.4°Cat760mmHg
• Flash Point: 177.8°C
• Appearance: /
• Density: 1.649g/cm³
• Vapor Pressure: 1.11E-05mmHg at 25°C
• Refractive Index: 1.732
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 6-bromoquinolin-8-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromoquinolin-8-amine(57339-57-8)
• EPA Substance Registry System: 6-bromoquinolin-8-amine(57339-57-8)

Safety Data

• Hazardous Substances Data: 57339-57-8(Hazardous Substances Data)

Usage

General Description

6-bromoquinolin-8-amine is a chemical compound with the molecular formula C9H7BrN2. It belongs to the class of quinoline derivatives and consists of a quinoline ring with a bromine atom at the 6th position and an amine group at the 8th position. 6-bromoquinolin-8-amine has potential applications in the field of medicinal chemistry and pharmaceuticals due to its biological activities. It may be used as a building block in the synthesis of various pharmaceutical compounds, and its structure provides opportunities for further modification to enhance its biological properties. Additionally, 6-bromoquinolin-8-amine may also be used as a research tool in the development of new drugs and understanding biological processes.

InChI:InChI=1/C9H7BrN2/c10-7-4-6-2-1-3-12-9(6)8(11)5-7/h1-5H,11H2

Upstream product

• 68527-67-3 6-bromo-8-nitroquinoline 
• 875-51-4 4-Bromo-2-nitroaniline 
• 5332-25-2 6-bromoquinoline 
• 88-74-4 2-nitro-aniline 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 282547-57-3 8-(4-benzyl-piperazin-1-yl)-6-bromo-quinoline 
• 857947-82-1 N-acetyl-sulfanilic acid-[(6-bromo-[8]quinolyl)-(2-diethylamino-ethyl)-amide] 
• 139399-64-7 6-bromo-8-quinolinol 
• 40000-20-2 5-bromo-1,10-phenanthroline 

Relevant articles and documents

Influence of Functionalized Substituents on the Electron-Transfer Abilities of Copper Guanidinoquinoline Complexes

The influence of functionalized ligands on the electron-transfer abilities of copper guanidinoquinoline complexes as entatic state models has been examined. An electron donating group (OCH3) or electron withdrawing group (Br) was introduced in 6-position of the quinoline unit of the ligands TMGqu and DMEGqu. The electron self-exchange rates k11 of the copper complexes with these ligands were determined using the Marcus cross relation. The k11 values of the functionalized complexes are smaller or equal to the values of their unsubstituted forms. These results were complemented by the examination of the reorganization energies of the electron-transfer via Eyring theory and DFT calculations. The higher reorganization energies of the [Cu(DMEG6Xqu)2]+/2+ (X = H, Br, OCH3) systems correspond with their decelerated electron-transfer velocities. Additionally, the calculated molecular electrostatic potentials show the influence of the functional groups on the electron-transfer. With the addition of the substituent a further charge distribution over the CH3O-/Br-group leads to a larger reorganization required during the oxidation reaction. The impact of the functionalization of the ligand on the electron-transfer of the [Cu(GUA6Xqu)2]+/2+ cations reveals a closer insight in the electronic structure of the complexes and its influence on their electron-transfer abilities.

ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise (I) wherein: Ra, R1, R2 and R3 are each, independently, hydrogen, or a substituent selected from halogen, CF3, alkyl, alkoxy, MeSO2, amino or aminocarbonyl (each optionally substituted by one or two groups selected from alkyl and benzyl) carboxy, or alkoxycarbonyl; or two adjacent of Ra and R1-4 together can form a 5-7 membered carbocyclic or heterocyclic ring which is optionally substituted by a substituent defined above; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, arylalkyl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, alkoxy or benzyloxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is CH or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.