573676-05-8

Basic information

• Product Name: 2-(4-METHYL-3-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRIDINE
• Synonyms: 2-(4-METHYL-3-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRIDINE
• CAS NO: 573676-05-8
• Molecular Formula: C₁₃H₉F₃N₂O₂
• Molecular Weight: 282.2179696
• Mol File: 573676-05-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-METHYL-3-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYL-3-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRIDINE(573676-05-8)
• EPA Substance Registry System: 2-(4-METHYL-3-NITROPHENYL)-3-(TRIFLUOROMETHYL)PYRIDINE(573676-05-8)

Safety Data

• Hazardous Substances Data: 573676-05-8(Hazardous Substances Data)

Usage

Usage

Commonly used in organic synthesis as a building block in the preparation of various pharmaceuticals and agrochemicals.

Trifluoromethyl group

Attracts drug design and discovery due to its ability to influence the pharmacokinetic and physicochemical properties of potential compounds.

Nitrophenyl substituent

Often used as a directing group in metal-catalyzed reactions, making the compound useful in the production of more complex organic molecules.

Methyl group

Further modifies the reactivity and properties of the compound in various applications.

Upstream product

• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 
• 5720-05-8 4-methylphenylboronic acid 
• 573676-03-6 2-(p-tolyl)-3-(trifluoromethyl)pyridine 

Downstream Products

• 1220632-23-4 2-amino-4-(3-trifluoromethylpyridin-2-yl)benzoic acid methyl ester 
• 1359648-03-5 2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzoic acid 
• 573680-40-7 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide 
• 573675-87-3 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide 
• 717115-87-2 N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide 
• 573675-81-7 7-(3-trifluoromethyl-pyridin-2-yl)-3H-quinazolin-4-one 
• 573676-09-2 2-amino-4-(3-trifluoromethylpyridin-2-yl)benzoic acid 
• 573675-83-9 4-chloro-7-(3-trifluoromethylpyridin-2-yl)quinazoline 
• 573676-07-0 2-nitro-4-(3-trifluoromethylpyridin-2-yl)benzoic acid 

Relevant articles and documents

Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists

The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a nonselective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antago

From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist

Bioisosteric replacement of piperazine with an aryl ring in lead VR1 antagonist 1 led to the biarylamide series. The development of B-ring SAR led to the conformationally constrained analog 70. The resulting aminoquinazoline 70 represents a novel VR1 anta

SUBSTITUTED CINNOLIN-4-YLAMINES

Substituted cinnolin-4-ylamines are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activityin vivo or in vitro, and are particularly useful in the treatmen