574-96-9 Usage
Description
1-HYDROXY-2-NAPHTHALDEHYDE, also known as β-naphthol aldehyde, is an organic compound with the molecular formula C11H8O2. It is a pale yellow crystalline solid that is soluble in organic solvents and exhibits a characteristic aromatic odor. 1-HYDROXY-2-NAPHTHALDEHYDE is known for its chemical reactivity and is widely utilized in the synthesis of various pharmaceutical compounds and organic molecules.
Uses
Used in Pharmaceutical Industry:
1-HYDROXY-2-NAPHTHALDEHYDE is used as a reagent for the synthesis of naphthofurancarboxamides, which serve as melanin concentrating hormone receptor 1 (MCHR1) antagonists. These antagonists are of significant interest in the development of treatments for various conditions, including obesity, depression, and sleep disorders, as they help regulate the balance of melanin-concentrating hormone in the body.
1-HYDROXY-2-NAPHTHALDEHYDE is also used as a reagent in the synthesis of hydropyridinylphenoxyacetohydrazones, a class of compounds that exhibit anticonvulsant, anti-inflammatory, and analgesic properties. These compounds have potential applications in the development of new drugs for the treatment of epilepsy, pain management, and inflammation-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 574-96-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 574-96:
(5*5)+(4*7)+(3*4)+(2*9)+(1*6)=89
89 % 10 = 9
So 574-96-9 is a valid CAS Registry Number.
574-96-9Relevant articles and documents
Insertion of arynes into the carbon-oxygen double bond of amides and its application into the sequential reactions
Yoshioka, Eito,Miyabe, Hideto
experimental part, p. 179 - 189 (2012/02/15)
The reaction of arynes, generated from ortho-(trimethylsilyl)aryl triflates, with the CO bond of formamides gave salicylaldehyde derivatives via the formation of formal [2+2] adducts. The sequential transformation of arynes into ortho-disubstituted arenes, o-aminoalkylphenols or o-hydroxyalkylphenols, was achieved by one-pot procedure using dialkylzincs.
PHOTOCHEMICAL REACTION OF NAPHTHYL α-NITROACRYLATES
Hirotani, Seiko,Zen, Shonosuke
, p. 2944 - 2947 (2007/10/02)
Photolysis of 2-nitro-3-(1-naphthyl)acrylates (1) in acetone gave novel naphthofuran-2-carboxylates (2) and 2-(alkoxyoxalylamino-methylene)naphthalen-1-ones (3). 2-Nitro-3-(2-naphthyl)acrylate also produced the furan derivative 2 on irradiation.A mechanism for this new photorearrangement reaction is described.KEYWORDS -- photochemical rearrangement; naphthyl α-nitroacrylate; naphtholfuran-2-carboxylate; 2-(ethoxyoxalylaminomethylene)naphthalen-1-one; α-keto-β-hydroxyiminoester