57477-82-4

Basic information

• Product Name: Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-(trifluoromethyl)-, hydrochloride
• CAS NO: 57477-82-4
• Molecular Formula: C12H16F3NO.ClH
• Molecular Weight: 283.721
• Mol File: 57477-82-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-(trifluoromethyl)-, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-(trifluoromethyl)-, hydrochloride(57477-82-4)
• EPA Substance Registry System: Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-(trifluoromethyl)-, hydrochloride(57477-82-4)

Safety Data

• Hazardous Substances Data: 57477-82-4(Hazardous Substances Data)

Upstream product

• 2832-19-1 2-Chloro-N-(hydroxymethyl)acetamide 
• 57477-80-2 2-trifluoromethyl-4-(1,1-dimethylethyl)phenol 
• 57477-84-6 3-trifluoromethyl-5-tert-butyl salicylaldehyde oxime 
• 7440-18-8 ruthenium 
• 59019-04-4 2-(2-Chloracetamidomethyl)-4-tert.-butyl-6-trifluormethyl-phenol 
• 444-30-4 2-(trifluoromethyl)phenol 

Relevant articles and documents

2-(Aminomethyl)phenols, a new class of saluretic agents. I. Effect of nuclear substitution

A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2,2(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenyl, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.

Method of treating autoimmune diseases

3,4-Dihydrospiro-2H-1,3-benzoxazines and pharmaceutical compositions thereof are useful in the treatment of autoimmune diseases.