57500-53-5

Basic information

• Product Name: 2-Thiophenecarboxaldehyde, 4-nitro- (6CI,7CI,9CI)
• Synonyms: 2-Thiophenecarboxaldehyde, 4-nitro- (6CI,7CI,9CI);2-Thiophenecarboxaldehyde, 4-nitro-;4-Nitro-thiophene-2-carbaldehyde
• CAS NO: 57500-53-5
• Molecular Formula: C₅H₃NO₃S
• Molecular Weight: 157.14722
• Product Categories: ALDEHYDE
• Mol File: 57500-53-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 35-37 °C
• Boiling Point: 126-131 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.534±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Thiophenecarboxaldehyde, 4-nitro- (6CI,7CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxaldehyde, 4-nitro- (6CI,7CI,9CI)(57500-53-5)
• EPA Substance Registry System: 2-Thiophenecarboxaldehyde, 4-nitro- (6CI,7CI,9CI)(57500-53-5)

Safety Data

• Hazardous Substances Data: 57500-53-5(Hazardous Substances Data)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 

Downstream Products

• 93282-96-3 4-nitro-thiophene-2-carbaldehyde phenylhydrazone 
• 91182-62-6 4-nitro-thiophene-2-carbaldehyde-(4-bromo-phenylhydrazone) 
• 13138-70-0 4-nitro-2-thiophenecarboxylic acid 
• 946884-84-0 5-(4-isopropoxyphenoxy)thiophene-2-carbaldehyde 
• 42137-24-6 4-nitrothiophene-2-carbonitrile 
• 134890-74-7 C₂₀H₂₁N₃O₅S₂ 
• 134890-88-3 C₁₈H₁₇N₃O₅S₂ 
• 134890-69-0 2-{[Ethyl-(5-{[(E)-4-methoxy-phenylimino]-methyl}-thiophen-3-yl)-amino]-methylene}-malonic acid diethyl ester 
• 134890-71-4 4-Ethyl-2-{[(E)-4-methoxy-phenylimino]-methyl}-7-oxo-4,7-dihydro-thieno[3,2-b]pyridine-6-carboxylic acid ethyl ester 
• 134890-66-7 2-[(5-{[(E)-4-Methoxy-phenylimino]-methyl}-thiophen-3-ylamino)-methylene]-malonic acid diethyl ester 
• 134890-91-8 4-Ethyl-2-{[(E)-4-methoxy-phenylimino]-methyl}-7-oxo-4,7-dihydro-thieno[3,2-b]pyridine-6-carboxylic acid 
• 56921-01-8 5-methyl-4-nitro-thiophene-2-carboxylic acid methyl ester 
• 92159-29-0 4-(4-nitro-thiophen-2-ylmethylene)-2-phenyl-4H-oxazol-5-one 

Relevant articles and documents

Synthesis, protolytic equilibria, and antimicrobial action of nifuroxazide analogs

The present paper reports on the synthesis of four hydrazones derived from 5-nitro-2-furfural, 5-nitro-2-thiophenal, isoniazid, 2,4- and 3,4-dihydroxy-N′-methylenebenzohydrazide. The acid-base dissociation constants of these compounds were determined in an aqueous solution. The protolytic equilibria-related ability of hydrazones to “sense” anions in dimethyl sulfoxide-containing water of different concentrations is studied using spectrophotometry, NMR spectroscopy, and quantum chemistry methods. The antimicrobial action of the hydrazones was tested and compared with that of the known drug nifuroxazide.

Ethylammonium nitrate (EAN)/Tf2O and EAN/TFAA: Ionic liquid based systems for aromatic nitration

Acting as in situ sources of triflyl nitrate (TfONO2) and trifluoroacetyl nitrate (CF3COONO2), the EAN/Tf 2O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid as solvent, are powerful electrophilic nitrating reagents for a wide variety of aromatic and heteroaromatic compounds. Comparative nitration experiments indicate that EAN/Tf2O is superior to EAN/TFAA for nitration of strongly deactivated systems. Both systems exhibit low substrate selectivity (K T/KB = 5-10) in (Figure presented) between values reported for covalent nitrates and preformed nitronium salts.

Synthesis of the fused heterobicycles 5-pyridin-2-yl-thieno[3,2-b]pyridine, 6-pyridin-2-yl-thieno[2,3-b]pyridine and 6-pyridin-2-yl-thieno[3,2-c]pyridine

Three new pyridyl thienopyridines, 5-pyridin-2-yl-thieno[3,2-b]pyridine, 6-pyridin-2-yl-thieno[2,3-b]pyridine and 6-pyridin-2-yl-thieno[3,2-c]pyridine, have been synthesized, each through a different synthetic sequence. Overall yields ranged from 8% to 32%. Georg Thieme Verlag Stuttgart.