5751-81-5 Usage
Description
2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester, also known as Ethyl 5-methylthiophene-2-carboxylate, is an organic compound derived from thiophene. It is characterized by the presence of a methyl group and a carboxylate ester functional group, which contribute to its chemical properties and reactivity.
Uses
Used in Chemical Synthesis:
2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester is used as a reactant for the preparation of dithienylmaleimides. This application is due to its reactivity in various chemical reactions, such as Perkin condensation, aminolysis, and Suzuki coupling.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester is used as a building block for the synthesis of various therapeutic compounds. Its unique chemical structure allows for the development of new drugs with potential applications in treating different medical conditions.
Used in Material Science:
2-Thiophenecarboxylic acid, 5-Methyl-, ethyl ester is also utilized in the field of material science for the development of novel materials with specific properties. Its incorporation into polymers and other materials can lead to improved performance characteristics, such as enhanced stability, conductivity, or optical properties.
Check Digit Verification of cas no
The CAS Registry Mumber 5751-81-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,5 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5751-81:
(6*5)+(5*7)+(4*5)+(3*1)+(2*8)+(1*1)=105
105 % 10 = 5
So 5751-81-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H10O2S/c1-3-10-8(9)7-5-4-6(2)11-7/h4-5H,3H2,1-2H3
5751-81-5Relevant articles and documents
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Grose,Campaigne
, p. 3258 (1949)
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β-Nitroacrylates as Starting Materials of Thiophene-2-Carboxylates Under Continuous Flow Conditions
Chiurchiù, Elena,Patehebieke, Yeersen,Gabrielli, Serena,Ballini, Roberto,Palmieri, Alessandro
, p. 2042 - 2047 (2019/03/13)
We report herein a general and efficient continuous flow-based protocol for synthesizing thiophene-2-carboxylates starting from ketal-functionalized β-nitroacrylates. The protocol involves (i) a promoter-free conjugate addition of thioacetic acid to β-nitroacrylates, (ii) a base-induced elimination of nitrous acid, and (iii) a final acid-promoted domino cyclization-aromatization process to afford the title targets. Thanks to the means of the flow chemistry and the use of solid supported systems, the three steps were combined in a whole flow chemical process, by which the products were isolated in good to excellent overall yields (38–88%). (Figure presented.).
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease
Rabal, Obdulia,Sánchez-Arias, Juan A.,Cuadrado-Tejedor, Mar,de Miguel, Irene,Pérez-González, Marta,García-Barroso, Carolina,Ugarte, Ana,Estella-Hermoso de Mendoza, Ander,Sáez, Elena,Espelosin, Maria,Ursua, Susana,Haizhong, Tan,Wei, Wu,Musheng, Xu,Garcia-Osta, Ana,Oyarzabal, Julen
supporting information, p. 506 - 524 (2018/03/21)
We have identified chemical probes that act as dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors (>1 log unit difference versus class I HDACs) to decipher the contribution of HDAC isoforms to the positive impact of dua
